Naslov
Ketogenic diet and its potential effects on DMT2 neuropathy and various pathophysiological processes underlying neurodegenerative diseases

Autori
Grbavac, Josip ; Sablić, Marko ; Horvat, Helena ; Firi, Lucija ; Viljetić, Barbara

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
OSCON Book of Abstracts / Pavlović, Vedrana - Osijek : J.J. STROSSMAYER UNIVERSITY OF OSIJEK FACULTY OF MEDICINE JOSIPA HUTTLERA 4, OSIJEK, 2023, 153-153

ISBN
978-953-7736-64-4

Skup
5 TH INTERNATIONAL TRANSLATIONAL MEDICINE CONGRESS OF STUDENTS AND YOUNG PHYSICIANS

Mjesto i datum
Osijek, Hrvatska, 30.03.2023. - 01.04.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DMT2, ketogenic diet, ketosis, neuroinflammation

Sažetak
Introduction: The ketogenic diet (KD) is a very low carbohydrate, high fat diet. It involves a drastic reduction in carbohydrate intake and its replacement with fat intake. This reduction in carbohydrates puts the body into ketosis, a metabolic state in which ketone bodies predominate as an energy source. In patients with type 2 diabetes mellitus (DMT2), KD has been shown to be effective in weight loss, reducing hyperinsulinemia, and improving insulin sensitivity. There are also interesting findings of beneficial effects on DMT2 neuropathy and various neurodegenerative diseases. Although the mechanism is not fully understood, KD has been used to treat seizures since the days of early empirical medicine. The question is how this diet and its metabolites affect the CNS. The answer may represent a new approach to the treatment of certain diseases. In this review, we try to explain what the cause of the beneficial effect could be and suggest further research that could explain the relationship between diet and CNS. Review: KD appears to be beneficial in almost all aspects of glycemic control. When used in real patients, some patients were able to stop taking diabetes medications. KD has been shown to affect mechanisms of neuroinflammation, such as enhancing mitochondrial respiration, reducing reactive oxygen species and intracellular signaling mediators, increasing autophagy, and modulating gut microbiota. Conclusion: Further research is needed to evaluate KD as a potential non-pharmacological treatment for DMT2 and various neurodegenerative diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA