Naslov
Are all hyperinflammatory syndromes after COVID-19 MIS-C?

Autori
Stevanović, Vedran ; Didović, Diana ; Stemberger Marić, Lorna ; Tešović, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, stručni

Izvornik
Book of abstracts of 3RD SOUTH-EAST EUROPEAN CONFERENCE ON TRAVEL, TROPICAL, MIGRATION MEDICINE AND HIV and 4th CROATIAN CONGRESS ON TRAVEL, TROPICAL, MIGRATION MEDICINE & HIV / - , 2021, 43-43

Skup
3RD SOUTH-EAST EUROPEAN CONFERENCE ON TRAVEL, TROPICAL, MIGRATION MEDICINE AND HIV and 4th CROATIAN CONGRESS ON TRAVEL, TROPICAL, MIGRATION MEDICINE & HIV

Mjesto i datum
Zadar, Hrvatska, 16.09.2021. - 19.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
hyperinflammatory syndromes ; MIS-C

Sažetak
Objectives: Multi-system inflammatory syndrome in children (MIS-C) is a rare complication of SARS-CoV-2 infection defined when there is no other obvious cause of multi-system inflmamation. Bacterial co-infection and secondary bacterial infection are considered critical risk factors for the severity and mortality rates of COVID-19. We present a 10-year-old boy with invasive meningococcal disease (IMD) and SARS-CoV- 2 co-infection. Case Report: Previously healthy 10-year-old boy presented with fever, cough, nausea and headache. On the 4th day of illness, diagnosis of COVID-19 was made by positive RT-PCR for SARS-CoV-2 from nasopharyngeal swab and the boy was discharged home. However, due to the ongoing fever and malaise he was admitted three days later as a possible MIS-C. At admission, he was hypothermic (34.9°C), hypotensive (RR 96/65 mmHg), with positive meningeal signs and petechial-purpuric rash on the extremities, abdomen and gluteus. Upon suspicion of IMD, the ceftriaxone treatment was started. His initial laboratory results included: procalcitonin of >100 mcg/L, CRP of 310 mg/L, WBC count of 19.9 x 109/L with relative neutrophilia of 91%, platelet count of 111 x 109/L, PV of 46%, D-dimers of 34.48 mg/L, NT-pro- BNP of 6099 ng/L and IL-6 of 1691 ng/L. Serology for SARS-CoV-2 was positive (IgG 77.9 IU/ml) and RT-PCR for Neisseria meningitidis from blood was positive for serogroup B. Chest X-ray, echocardiography and brain MSCT were unremarkable. Treatment included ceftriaxone for 10 days with no need for ICU treatment. During hospital stay he developed post-infectious erythema nodosum, but otherwise recovered completely. Conclusion: SARS-CoV-2 predisposition to invasive bacterial infections remains poorly explained due to lack of reported cases. As did in our patient, IMD may trail a preceding infection by around 2 weeks. Surveillance for invasive bacterial infection is important to characterise and to help protect against bacterial co-infection in the context of the ongoing COVID-19 pandemic.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti

POVEZANOST RADA