Naslov
Ki67, estrogen and androgen receptors in oral squamous cell carcinoma-a pilot study

Autori
Vucicevic Boras, V ; Tomasoc-Loncaric, C ; , Gabric, D ; Sekerija, M ; Vrdoljak, B ; Filipovic, M ; Fucic, A

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts 28-28 / - , 2017, 28-28

Skup
26th Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 02.06.2017. - 02.06.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
OSCC ; Ki67 ; estrogen receptor ; progesteron receptor

Sažetak
Oral squamous cell carcinoma (OSCC) is a cancer type with a poor survival rate (lethality rate of 48%) and still obscure biology. In a complex tumor microenvironment, estrogen (ER) and androgen receptors (AR) have been suggested to take part in tumor promotion, progression and metastasis. The role of stromal cells in the biology of a tumor is still under investigation. It has been suggested that activated stromal cells within OSCC may produce signal molecules crucial for the development of metastases. Thus, the interaction of key molecules in neoplastic and stromal cells may significantly contribute to the understanding of tumor biology. The aim of the current study was to investigate the association of ER and AR with Ki67 as a biomarker of cell division dynamics in the epithelial and stromal cells of OSCC. In this pilot study 42 male patients were included (mean age 50 years). Immunohistochemistry was performed on paraffin blocks. For each subject 500 epithelial and stromal cells were analysed for ER, AR and Ki67 levels. Results show that ER was not detectable either in the epithelial or in the stromal cells except anecdotally in the salivary glands. The presence of AR positive epithelial cells was significantly associated with AR positive stromal cells (p=0.01). Although, not reaching significance due to the low number of subjects, within AR positive epithelial and stromal cells higher Ki67 levels were detected in stromal cells when compared to the AR negative epithelial and stromal cells thus suggesting impact of testosterone on their division rate. The future aim is to include a larger number of patients and other biomarkers in order to achieve a better understanding of the molecular mechanisms that mediate OSCC metastasis and suggest novel therapeutic targets

Izvorni jezik
Engleski

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