Pregled bibliografske jedinice broj: 1269465
Circulating Cell-Free Tumor Deoxyribonucleic Acid Analysis as a Tool for the Diagnosis and Monitoring of Pediatric Solid Tumors
Circulating Cell-Free Tumor Deoxyribonucleic Acid Analysis as a Tool for the Diagnosis and Monitoring of Pediatric Solid Tumors // Turkish archives of pediatrics, 58 (2023), 3; 241-249 doi:10.5152/TurkArchPediatr.2023.23014 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1269465 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Circulating Cell-Free Tumor Deoxyribonucleic Acid
Analysis as a Tool for the Diagnosis and
Monitoring of Pediatric Solid Tumors
Autori
Zaninović, Luca ; Bašković, Marko ; Katušić Bojanac, Ana ; Ježek, Davor
Izvornik
Turkish archives of pediatrics (2757-6256) 58
(2023), 3;
241-249
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
children ; circulating cell-free tumor DNA ; diagnostic ; solid tumor
Sažetak
The utility of cell-free tumor deoxyribonucleic acid analysis is currently being evaluated in a wide range of clinical studies. The validity of cell-free tumor deoxyribonucleic acid analysis methods used for screening and detecting malignant diseases, monitoring the effectiveness of treatment and disease progression, and identifying potential relapse is tested. Molecular technologies used for cell-free tumor deoxyribonucleic acid analysis include targeted polymerase chain reaction assays and next- generation sequencing approaches along with newly introduced epigenetic analysis methods such as methylation-specific polymerase chain reaction. The aim of this review was to compare the methods, pitfalls, and advantages of tests developed for the analysis of cell-free tumor deoxyribonucleic acid in the diagnosis and treatment of pediatric solid tumors. For this purpose, the PubMed database was searched for articles published in the last 10 years, in English, that investigated a human cohort aged 0 to 18 years. A total of 272 references were analyzed. A total of 33 studies were included in the review. Cell-free tumor deoxyribonucleic acid analysis has emerged as a promising novel approach that could potentially bring a significant improvement in the field of pediatric oncology, but the implementation of cell-free tumor deoxyribonucleic acid in clinical practice is largely hindered by the lack of standardized methods for processing and analysis.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
--KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Ježek, Davor; Vukičević, Slobodan) ( CroRIS)
Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb,
Sveučilište u Zagrebu,
Klinika za dječje bolesti
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi turkarchpediatr.org pubmed.ncbi.nlm.nih.govCitiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Emerging Sources Citation Index (ESCI)
- Scopus
