Naslov
Efficacy of repetitive Transcranial magnetic stimuilation with H7-coil in the treatment of Tinnitus: Protocol for Phase II-A, proof of concept, randomized, sham-controlled, doubble blind clinical trial

Autori
Gereš, N ; Zečević Penić, S ; Milovac, Ž ; Sučić, S ; Gajšak, T ; Koret, B ; Gerlach , J ; Prskalo-Čule, D ; Svetinović, D ; Tunjić- Vukadinović, N ; Orgulan, I ; Požgaj, V ; Košec, A ; Geber, G ; Ivkić, G ; Vuk Pisk, S ; Filipčić, I

Izvornik
Psychiatria Danubina (0353-5053) 34 (2022), 3; S54-S55

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, znanstveni

Ključne riječi
Tinnitus ; treatment standard ; rTMS

Sažetak
We conducted a meta-analysis of randomized sham- controlled, double-blind trials. Instead of a systematic search for the primary studies and new risk-of-bias assessment, we used 13 systematic reviews and meta-analyses that were published by February 25, 2022. We used a random-effects model, and analyzed the standardized effect sizes, and instead of only calculating the confidence intervals, as was done in literally all 13 meta- analyzes, we calculated the 95% prediction intervals to respect the uncertainty in estimating between-study variance. Results: Total number of eligible studies was 42, of witch large number did not define the primary outcome. In the final analysis, we included 26 studies with 549 patients in active and 537 in passive sham arms. The overall effect of rTMS on severity of tinnitus was Hedges g= -0.39 (95% CI -0.57 ; -0.21 ; 95% prediction interval -1.00 ; 0.22) (Figure 1).Too many randomized sham-controlled trials on the efficacy of rTMS on tinnitus and reporting of their results are of unsatisfactory quality. The whole body of literature is fragmented into small, too often poorly designed trials with exclusive/new protocols and presumably low reproducibility. The whole field would probably benefit from larger, better theoretically founded studies, replications of the most promising experiments, and the empirically founded patient- oriented approach that will respect the tinnitus phenotype heterogeneity and the existence of distinct patient subpopulations. In this area of research, the race for the ad-hoc discovery of the Holy Grail of rTMS perfect protocol should be stopped, and the traditional scientific paradigm of theoretically grounded gradual improvement on previous studies and theories should be adhered to.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA