Naslov
TO CHOOSE OR NOT TO CHOOSE HYDROPHOBIC DEEPEUTECTIC SOLVENTS FOR PHARMACEUTICALAPPLICATION

Autori
Bagović, Martina ; Panić, Manuela ; Jakopović, Željko ; Cvjetko Bubalo Marina ; Radojčić Redovniković, Ivana ; Radošević Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstract of 2nd Greenering International Conference / - , 2023, 170-170

Skup
2nd Greenering International Conference

Mjesto i datum
Valladolid, Španjolska, 21.03.2023. - 23.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antioxidant activity ; antimicrobial activity ; hydrophobic deep eutectic solvents ; physicochemical characterization

Sažetak
Recently, a new window is opened with subclass of DESs, a hydrophobic DESs (hDESs), which application could be of great value for the pharmaceutical and cosmetic industry. It could be expected that hDESs can overpass the problems that occur with substances poorly soluble in water by increasing their solubility, permeability and stability. To be safely used in aforementioned industries it is of great importance to test hDESs cytotoxicity, solubility and permeability potential. Therefore, in the presented work we have prepared eight hDESs which are physico-chemically characterized and their cytotoxic profile was assessed on two human cell lines. The Parallel Artificial Membrane Permeability Assay (PAMPA) was applied as an in vitro model of passive permeation to determine potential of hDESs to be used as a solvent or a carrier for different compounds of interest. Furthermore, properties important for stability of formulation are also assessed i.e. antioxidant and antimicrobial potential of eight synthetized hDESs were evaluated based on ORAC method and disc diffusion assay.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA