Naslov
How does reinduction of first-line chemotherapy in patients with metastatic colorectal cancer impact outcomes? Experience from the University Hospital for Tumors, Zagreb, Croatia

Autori
Pavlović, MIrjana ; Lepetić, Petra ; Vazdar, Ljubica ; Linarić, Petra ; Tečić Vuger, Ana ; Šeparović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Annals of Oncology Abstract Book of the ESMO 23rd World Congress on Gastrointestinal Cancer / - , 2021, 101-101

Skup
ESMO 23rd World Congress on Gastrointestinal Cancer

Mjesto i datum
Online, 30.06.2021. - 03.07.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Colorectal cancer, chemotherapy, reinduction, metastatic colorectal cancer (mCRC) , overall survival (OS)

Sažetak
Evidence related to reinduction of first-line therapy after maintenance in metastatic colorectal cancer (mCRC) patients remains insufficient. We hypothesized that prolongation of first-line therapy may affect patient's probability of receiving second-line therapy and therefore, we aimed to investigate how reinduction and prolongation of the first-line therapy affects overall survival (OS). The results show that reinduction had a positive effect on the OS. This is an end-result of many effects, with biological features of the tumour being probably among the strongest ones. Patients who have less aggressive underlying tumour biology (left sided tumors) seem to be more likely to experience reinduction and subsequent lines of treatment. Therefore, it seems that tumor biology is the strongest predictor of the OS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA