Naslov
Priprava i konformacijska analiza nove vrste ferocenskih peptidomimetika
(Synthesis and conformational analysis of novel type of ferrocene peptidomimetics)

Autori
Stipčić, Tea ; Roca, Sunčica ; Barišić, Lidija ; Kovačević, Monika

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIII. Susret mladih kemijskih inženjera : knjiga sažetaka = XIII Meeting of Young Chemical Engineers : Book of Abstracts / Dejanović, Igor ; Vrsaljko Domagoj ; Žižek, Krunoslav - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2020, 94-94

ISBN
978-953-6894-71-0

Skup
XIII. susret mladih kemijskih inženjera (SMLKI 2020) = XIII Meeting of Young Chemical Engineers

Mjesto i datum
Zagreb, Hrvatska, 20.02.2020. - 21.02.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
depsipeptidi ; peptidomimetici ; ferocen ; spektroskopska analiza ; vodikova veza
(depsipeptide ; peptidomimetics ; ferrocene ; spectroscopic analysis ; hydrogen bond)

Sažetak
The amide conjugates of 1, n-disubstituted ferrocenes and amino acids are well known for their ability to adopt the turn or -sheet-like structures [1-5], owing to the turn-inducing capacity of ferrocene scaffolds. Amide-to-ester substitutions in the peptide backbone have proven to be a good tool for evaluating of backbone hydrogen-bonding behaviour of the so-derived depsipeptides [6-7]. Herein, we describe the synthesis of depsipeptide analogue of the previously reported ferrocene peptides [2, 4]. The influence of the amide-to-ester substitution on the conformational properties of the depsipeptide 1 is explored by IR, NMR and CD spectroscopy.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija

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