Naslov
Possible immune mechanisms initiated by 7- ketocholesterol that contribute to synovial oxidative stress and inflammation

Autori
Drvar, Vedrana ; Legović, Dalen ; Čanadi Jurešić, Gordana ; Ćurko-Cofek, Božena ; Kehler, Tatjana ; Laskarin, Ana-Marija ; Nemčić, Emilio ; Laskarin, Gordana

Izvornik
Medical hypotheses (0306-9877) 175 (2023); 111078, 6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD68 ; 7-Ketocholesterol ; Macrophages ; Macrophage polarization ; Osteoarthritis ; Synovial tissue

Sažetak
Osteoarthritis (OA) is a chronic joint disease caused by both mechanical damage and metabolic factors, which intertwine in their pathogenetic pathways. We hypothesise that the oxidised cholesterol derivative, 7-ketocholesterol (7-KCh), represents a danger signal in the synovia of patients with OA and promotes low-grade inflammation. The study would aim to elucidate the possible immune mechanisms initiated by 7-KCh that contribute to oxidative stress and inflammation in the synovia and synovial CD68+ cells, which are mostly macrophages. The polarisation of synovial CD68+ cells, their tissue distribution in relation to T and natural killer (NK) cells, and the influence of 7-KCh on the phenotype and intracellular cytokine and chemokine production in suspension is worth analysing. We envisage that this research would contribute to a better understanding of the biology of CD68+ macrophages influenced by 7-KCh and encourage the development of therapeutic approaches based on directing macrophage polarisation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA