Naslov
The Influence of Hemochromatosis Gene (HFE) Mutations on SARS-CoV-2 Susceptibility and COVID- 19 Severity

Autori
Ristić, Smiljana ; Milić, Sandra ; Tatalović, Tanja ; Bilobrk, Matea ; Rončević, Dobrica ; Ćurko-Cofek, Božena ; Barac-Latas, Vesna ; Starčević Čizmarević, Nada

Izvornik
Balkan Medical Journal (2146-3123) 40 (2023); 229-231

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
HFE ; Mutation ; SARS-CoV-2 ; COVID-19

Sažetak
Coronavirus disease-2019 (COVID-19) is an extremely complex disease wherein numerous genetic and epigenetic factors determine the variable phenotypic manifestations. Owing to the wide range of symptoms, ranging from an asymptomatic condition to a mild, severe, or critical disease state, host genetics have been hypothesized to influence susceptibility to COVID-19, as in other infections. We hypothesized that HFE mutations may be a risk factor for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection and affect the outcomes of COVID-19 in patients with suspected HH. Our results suggest that HFE polymorphisms do not affect susceptibility / resistance to SARS-CoV-2 infection or the clinical course of COVID-19 in patients with altered iron parameters.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA