Naslov
Long-term Consequences of Polycystic Ovary Syndrome

Autori
Crumbach, Monika ; Škrgatič, Lana, Goluža, Trpimir ; Pavičić Baldani, Dinka

Izvornik
Gynaecologia et perinatologia (1330-0091) 25 (2016), 2; 53-58

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Polycystic ovary syndrome, cardiometabolic risk factors

Sažetak
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It shares many features with the metabolic syndrome (insulin resistance, an increase in body mass index, changes in lipidogram, increases in C-reactive protein due to chronic inflammation). As a long-term consequence, development of cardiovascular disease (CVD) is likely. The purpose of this retrospective observational study was to explore if cardiometabolic risk factors (BMI, HOMA-IR, total cholesterol, TG, LDL-C, HDL-C, CRP) worsen over time in PCOS patients. The data of 36 PCOS patients aged 26.5  6.4, in whom the diagnosis was made according to the Rotterdam criteria, was included in the study. The metabolic parameters were taken from hospital records of University Hospital Petrova Gynecological Clinic in Zagreb, Croatia. We included laboratory values measured at the starting point of the study, in 2007, and after nine years, in 2016. No significant worsening of cardiometabolic risk factors was found after the nine years. Only the percentage of PCOS patients with a BMI > 25 increased from 25.0% to 33.3% (P = 0.002). Further studies should be conducted with a larger sample size and longer duration of observation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA