Naslov
Combined ovulation triggering with GnRH agonist and hCG in IVF patients

Autori
Kasum, Miro ; Kurdija, Christian ; Orešković, Slavko ; Čehić, Ermin ; PAvičić Baldani, Dinka ; Škrgatić, Lana

Kolaboracija
Human Reproduction Unit, Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina

Izvornik
Gynecological endocrinology (0951-3590) 8 (2016); 1-57

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Combined ovulation triggering ; GnRH agonist trigger ; double trigger ; dual trigger ; hCG-triggering.

Sažetak
The aim of the review is to analyse the combination of a gonadotrophin releasing hormone (GnRH) agonist with a human chorionic gonadotrophin (hCG) trigger, for final oocyte maturation in in vitro fertilisation (IVF) cycles. The concept being a ''dual trigger'' combines a single dose of the GnRH agonist with a reduced or standard dosage of hCG at the time of triggering. The use of a GnRH agonist with a reduced dose of hCG in high responders demonstrated luteal phase support with improved pregnancy rates, similar to those after conventional hCG and a low risk of ovarian hyperstimulation syndrome (OHSS). The administration of a GnRH agonist and a standard hCG in normal responders, demonstrated significantly improved live-birth rates and a higher number of embryos of excellent quality, or cryopreserved embryos. The concept of the ''double trigger" represents a combination of a GnRH agonist and a standard hCG, when used 40 and 34 h prior to ovum pick-up, respectively. The use of the ''double trigger" has been successfully offered in the treatment of empty follicle syndrome and in patients with a history of immature oocytes retrieved or with low/poor oocytes yield. Further prospective studies are required to confirm the aforementioned observations prior to clinical implementation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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