Naslov
The cardiometabolic effect of current management of polycystic ovary syndrome: strategies of prevention and treatment

Autori
Pavičić Baldani, Dinka ; Škrgatić, Lana ; Ougouag, Roya ; Kasum, Miro

Izvornik
Gynecological endocrinology (0951-3590) 34 (2018), 2; 87-91

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
PCOS ; anti-androgens ; cardiovascular risk factors ; cholesterol ; insulin sensitizers ; life style ; oral contraceptive pills ; treatment.

Sažetak
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Therapies, such as oral contraceptives (OCPs) and anti-androgenic medications used to manage the reproductive manifestations of PCOS, may themselves be the cause of cardiometabolic perturbations. Hence, strategies regarding the management of reproductive issues in PCOS encompass a patient-specific tailored approach. Factors that influence the cardiometabolic side effects arising during treatment of the reproductive manifestations of PCOS (hirsutism/anovulation) are also discussed in this paper in order to build future strategies to minimize the overall cardiometabolic risk.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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