Naslov
The signature of inverse hexagonal phase of phosphoethanolamine lipids

Autori
Maleš, Petra ; Bakarić, Danijela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
28HSKIKI : 28th Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog : Book of Abstracts / Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2023, 98-98

Skup
28.Croatian Meeting of Chemists and Chemical Engineers and 6th Symposium Vladimir Prelog

Mjesto i datum
Rovinj, Hrvatska, 28.03.2023. - 31.03.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Phosphoethanolamine ; Liposomes

Sažetak
The compositional variations of lipids in the myelin sheath are responsible for nerve conduction failure and neurodegeneration that may ultimately result in demyelinating diseases such as multiple sclerosis (MS). A significant enhancement of phosphoethanolamine (PE) lipids in myelin at pathological conditions is presumably associated with a greater probability that PE lipids, besides forming lamellar (L/L) structures, can be arranged in nonlamellar inverse hexagonal phase (HII) that structurally resembles to the vacuoles, similar to those caused by demyelination. When 1- palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine (POPE), as one of the most common lipids in myelin membrane, is suspended in water, along with L/L phases POPE can also form HII, distinguished by inverted lipid cylinders with the polar headgroups of lipids facing the water surroundings.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA