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Pregled bibliografske jedinice broj: 1263210

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

(The PRACTICAL consortium) Law, Philip J.; Timofeeva, Maria; Fernandez-Rozadilla, Ceres; Broderick, Peter; Studd, James; Fernandez-Tajes, Juan; Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia et al.
Association analyses identify 31 new risk loci for colorectal cancer susceptibility // Nature communications, 10 (2019), 1; 2154, 15 doi:10.1038/s41467-019-09775-w (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1263210 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Autori
Law, Philip J. ; Timofeeva, Maria ; Fernandez-Rozadilla, Ceres ; Broderick, Peter ; Studd, James ; Fernandez-Tajes, Juan ; Farrington, Susan ; Svinti, Victoria ; Palles, Claire ; Orlando, Giulia ; Sud, Amit ; Holroyd, Amy ; Penegar, Steven ; Theodoratou, Evropi ; Vaughan-Shaw, Peter ; Campbell, Harry ; Zgaga, Lina ; Hayward, Caroline ; Campbell, Archie ; Harris, Sarah ; Deary, Ian J. ; Starr, John ; Gatcombe, Laura ; Pinna, Maria ; Briggs, Sarah ; Martin, Lynn ; Jaeger, Emma ; Sharma-Oates, Archana ; East, James ; Leedham, Simon ; Arnold, Roland ; Johnstone, Elaine ; Wang, Haitao ; Kerr, David ; Kerr, Rachel ; Maughan, Tim ; Kaplan, Richard ; Al-Tassan, Nada ; Palin, Kimmo ; Hänninen, Ulrika A. ; Cajuso, Tatiana ; Tanskanen, Tomas ; Kondelin, Johanna ; Kaasinen, Eevi ; Sarin, Antti-Pekka ; Eriksson, Johan G. ; Rissanen, Harri ; Knekt, Paul ; Pukkala, Eero ; Jousilahti, Pekka ; Salomaa, Veikko ; Ripatti, Samuli ; Palotie, Aarno ; Renkonen-Sinisalo, Laura ; Lepistö, Anna ; Böhm, Jan ; Mecklin, Jukka- Pekka ; Buchanan, Daniel D. ; Win, Aung-Ko ; Hopper, John ; Jenkins, Mark E. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Gallinger, Steven ; Duggan, David ; Casey, Graham ; Hoffmann, Per ; Nöthen, Markus M. ; Jöckel, Karl-Heinz ; Easton, Douglas F. ; Pharoah, Paul D. P. ; Peto, Julian ; Canzian, Federico ; Swerdlow, Anthony ; Eeles, Rosalind A. ; Kote-Jarai, Zsofia ; Muir, Kenneth ; Pashayan, Nora ; Henderson, Brian E. ; Haiman, Christopher A. ; Schumacher, Fredrick R. ; Al Olama, Ali Amin ; Benlloch, Sara ; Berndt, Sonja I. ; Conti, David V. ; Wiklund, Fredrik ; Chanock, Stephen ; Gapstur, Susan ; Stevens, Victoria L. ; Tangen, Catherine M. ; Batra, Jyotsna ; Clements, Judith ; Gronberg, Henrik ; Schleutker, Johanna ; Albanes, Demetrius ; Wolk, Alicja ; West, Catharine ; Mucci, Lorelei ; Cancel-Tassin, Géraldine ; Koutros, Stella ; Sorensen, Karina Dalsgaard ; Grindedal, Eli Marie ; Neal, David E. ; Hamdy, Freddie C. ; Donovan, Jenny L. ; Travis, Ruth C. ; Hamilton, Robert J. ; Ingles, Sue Ann ; Rosenstein, Barry S. ; Lu, Yong- Jie ; Giles, Graham G. ; Kibel, Adam S. ; Vega, Ana ; Kogevinas, Manolis ; Penney, Kathryn L. ; Park, Jong Y. ; Stanford, Janet L. ; Cybulski, Cezary ; Nordestgaard, Børge G. ; Maier, Christiane ; Kim, Jeri ; John, Esther M. ; Teixeira, Manuel R. ; Neuhausen, Susan L. ; De Ruyck, Kim ; Razack, Azad ; Newcomb, Lisa F. ; Gamulin, Marija ; Kaneva, Radka ; Usmani, Nawaid ; Claessens, Frank ; Townsend, Paul A. ; Gago- Dominguez, Manuela ; Roobol, Monique J. ; Menegaux, Florence ; Khaw, Kay-Tee ; Cannon-Albright, Lisa ; Pandha, Hardev ; Thibodeau, Stephen N. ; Harkin, Andrea ; Allan, Karen ; McQueen, John ; Paul, James ; Iveson, Timothy ; Saunders, Mark ; Butterbach, Katja ; Chang-Claude, Jenny ; Hoffmeister, Michael ; Brenner, Hermann ; Kirac, Iva ; Matošević, Petar ; Hofer, Philipp ; Brezina, Stefanie ; Gsur, Andrea ; Cheadle, Jeremy P. ; Aaltonen, Lauri A. ; Tomlinson, Ian ; Houlston, Richard S. ; Dunlop, Malcolm G.

Kolaboracija
The PRACTICAL consortium

Izvornik
Nature communications (2041-1723) 10 (2019), 1; 2154, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
colorectal cancer

Sažetak
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34, 627 CRC cases and 71, 379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb

Profili:

Avatar Url Petar Matošević (autor)

Avatar Url Marija Gamulin (autor)

Avatar Url Iva Kirac (autor)

Avatar Url Lina Zgaga (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(The PRACTICAL consortium) Law, Philip J.; Timofeeva, Maria; Fernandez-Rozadilla, Ceres; Broderick, Peter; Studd, James; Fernandez-Tajes, Juan; Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia et al.
Association analyses identify 31 new risk loci for colorectal cancer susceptibility // Nature communications, 10 (2019), 1; 2154, 15 doi:10.1038/s41467-019-09775-w (međunarodna recenzija, članak, znanstveni)
(The PRACTICAL consortium) (The PRACTICAL consortium) Law, P., Timofeeva, M., Fernandez-Rozadilla, C., Broderick, P., Studd, J., Fernandez-Tajes, J., Farrington, S., Svinti, V., Palles, C. & Orlando, G. (2019) Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nature communications, 10 (1), 2154, 15 doi:10.1038/s41467-019-09775-w.
@article{article, author = {Law, Philip J. and Timofeeva, Maria and Fernandez-Rozadilla, Ceres and Broderick, Peter and Studd, James and Fernandez-Tajes, Juan and Farrington, Susan and Svinti, Victoria and Palles, Claire and Orlando, Giulia and Sud, Amit and Holroyd, Amy and Penegar, Steven and Theodoratou, Evropi and Vaughan-Shaw, Peter and Campbell, Harry and Zgaga, Lina and Hayward, Caroline and Campbell, Archie and Harris, Sarah and Deary, Ian J. and Starr, John and Gatcombe, Laura and Pinna, Maria and Briggs, Sarah and Martin, Lynn and Jaeger, Emma and Sharma-Oates, Archana and East, James and Leedham, Simon and Arnold, Roland and Johnstone, Elaine and Wang, Haitao and Kerr, David and Kerr, Rachel and Maughan, Tim and Kaplan, Richard and Al-Tassan, Nada and Palin, Kimmo and H\"{a}nninen, Ulrika A. and Cajuso, Tatiana and Tanskanen, Tomas and Kondelin, Johanna and Kaasinen, Eevi and Sarin, Antti-Pekka and Eriksson, Johan G. and Rissanen, Harri and Knekt, Paul and Pukkala, Eero and Jousilahti, Pekka and Salomaa, Veikko and Ripatti, Samuli and Palotie, Aarno and Renkonen-Sinisalo, Laura and Lepist\"{o}, Anna and B\"{o}hm, Jan and Mecklin, Jukka- Pekka and Buchanan, Daniel D. and Win, Aung-Ko and Hopper, John and Jenkins, Mark E. and Lindor, Noralane M. and Newcomb, Polly A. and Gallinger, Steven and Duggan, David and Casey, Graham and Hoffmann, Per and N\"{o}then, Markus M. and J\"{o}ckel, Karl-Heinz and Easton, Douglas F. and Pharoah, Paul D. P. and Peto, Julian and Canzian, Federico and Swerdlow, Anthony and Eeles, Rosalind A. and Kote-Jarai, Zsofia and Muir, Kenneth and Pashayan, Nora and Henderson, Brian E. and Haiman, Christopher A. and Schumacher, Fredrick R. and Al Olama, Ali Amin and Benlloch, Sara and Berndt, Sonja I. and Conti, David V. and Wiklund, Fredrik and Chanock, Stephen and Gapstur, Susan and Stevens, Victoria L. and Tangen, Catherine M. and Batra, Jyotsna and Clements, Judith and Gronberg, Henrik and Schleutker, Johanna and Albanes, Demetrius and Wolk, Alicja and West, Catharine and Mucci, Lorelei and Cancel-Tassin, G\'{e}raldine and Koutros, Stella and Sorensen, Karina Dalsgaard and Grindedal, Eli Marie and Neal, David E. and Hamdy, Freddie C. and Donovan, Jenny L. and Travis, Ruth C. and Hamilton, Robert J. and Ingles, Sue Ann and Rosenstein, Barry S. and Lu, Yong- Jie and Giles, Graham G. and Kibel, Adam S. and Vega, Ana and Kogevinas, Manolis and Penney, Kathryn L. and Park, Jong Y. and Stanford, Janet L. and Cybulski, Cezary and Nordestgaard, B\orge G. and Maier, Christiane and Kim, Jeri and John, Esther M. and Teixeira, Manuel R. and Neuhausen, Susan L. and De Ruyck, Kim and Razack, Azad and Newcomb, Lisa F. and Gamulin, Marija and Kaneva, Radka and Usmani, Nawaid and Claessens, Frank and Townsend, Paul A. and Gago- Dominguez, Manuela and Roobol, Monique J. and Menegaux, Florence and Khaw, Kay-Tee and Cannon-Albright, Lisa and Pandha, Hardev and Thibodeau, Stephen N. and Harkin, Andrea and Allan, Karen and McQueen, John and Paul, James and Iveson, Timothy and Saunders, Mark and Butterbach, Katja and Chang-Claude, Jenny and Hoffmeister, Michael and Brenner, Hermann and Kirac, Iva and Mato\v{s}evi\'{c}, Petar and Hofer, Philipp and Brezina, Stefanie and Gsur, Andrea and Cheadle, Jeremy P. and Aaltonen, Lauri A. and Tomlinson, Ian and Houlston, Richard S. and Dunlop, Malcolm G.}, year = {2019}, pages = {15}, DOI = {10.1038/s41467-019-09775-w}, chapter = {2154}, keywords = {colorectal cancer}, journal = {Nature communications}, doi = {10.1038/s41467-019-09775-w}, volume = {10}, number = {1}, issn = {2041-1723}, title = {Association analyses identify 31 new risk loci for colorectal cancer susceptibility}, keyword = {colorectal cancer}, chapternumber = {2154} }
@article{article, author = {Law, Philip J. and Timofeeva, Maria and Fernandez-Rozadilla, Ceres and Broderick, Peter and Studd, James and Fernandez-Tajes, Juan and Farrington, Susan and Svinti, Victoria and Palles, Claire and Orlando, Giulia and Sud, Amit and Holroyd, Amy and Penegar, Steven and Theodoratou, Evropi and Vaughan-Shaw, Peter and Campbell, Harry and Zgaga, Lina and Hayward, Caroline and Campbell, Archie and Harris, Sarah and Deary, Ian J. and Starr, John and Gatcombe, Laura and Pinna, Maria and Briggs, Sarah and Martin, Lynn and Jaeger, Emma and Sharma-Oates, Archana and East, James and Leedham, Simon and Arnold, Roland and Johnstone, Elaine and Wang, Haitao and Kerr, David and Kerr, Rachel and Maughan, Tim and Kaplan, Richard and Al-Tassan, Nada and Palin, Kimmo and H\"{a}nninen, Ulrika A. and Cajuso, Tatiana and Tanskanen, Tomas and Kondelin, Johanna and Kaasinen, Eevi and Sarin, Antti-Pekka and Eriksson, Johan G. and Rissanen, Harri and Knekt, Paul and Pukkala, Eero and Jousilahti, Pekka and Salomaa, Veikko and Ripatti, Samuli and Palotie, Aarno and Renkonen-Sinisalo, Laura and Lepist\"{o}, Anna and B\"{o}hm, Jan and Mecklin, Jukka- Pekka and Buchanan, Daniel D. and Win, Aung-Ko and Hopper, John and Jenkins, Mark E. and Lindor, Noralane M. and Newcomb, Polly A. and Gallinger, Steven and Duggan, David and Casey, Graham and Hoffmann, Per and N\"{o}then, Markus M. and J\"{o}ckel, Karl-Heinz and Easton, Douglas F. and Pharoah, Paul D. P. and Peto, Julian and Canzian, Federico and Swerdlow, Anthony and Eeles, Rosalind A. and Kote-Jarai, Zsofia and Muir, Kenneth and Pashayan, Nora and Henderson, Brian E. and Haiman, Christopher A. and Schumacher, Fredrick R. and Al Olama, Ali Amin and Benlloch, Sara and Berndt, Sonja I. and Conti, David V. and Wiklund, Fredrik and Chanock, Stephen and Gapstur, Susan and Stevens, Victoria L. and Tangen, Catherine M. and Batra, Jyotsna and Clements, Judith and Gronberg, Henrik and Schleutker, Johanna and Albanes, Demetrius and Wolk, Alicja and West, Catharine and Mucci, Lorelei and Cancel-Tassin, G\'{e}raldine and Koutros, Stella and Sorensen, Karina Dalsgaard and Grindedal, Eli Marie and Neal, David E. and Hamdy, Freddie C. and Donovan, Jenny L. and Travis, Ruth C. and Hamilton, Robert J. and Ingles, Sue Ann and Rosenstein, Barry S. and Lu, Yong- Jie and Giles, Graham G. and Kibel, Adam S. and Vega, Ana and Kogevinas, Manolis and Penney, Kathryn L. and Park, Jong Y. and Stanford, Janet L. and Cybulski, Cezary and Nordestgaard, B\orge G. and Maier, Christiane and Kim, Jeri and John, Esther M. and Teixeira, Manuel R. and Neuhausen, Susan L. and De Ruyck, Kim and Razack, Azad and Newcomb, Lisa F. and Gamulin, Marija and Kaneva, Radka and Usmani, Nawaid and Claessens, Frank and Townsend, Paul A. and Gago- Dominguez, Manuela and Roobol, Monique J. and Menegaux, Florence and Khaw, Kay-Tee and Cannon-Albright, Lisa and Pandha, Hardev and Thibodeau, Stephen N. and Harkin, Andrea and Allan, Karen and McQueen, John and Paul, James and Iveson, Timothy and Saunders, Mark and Butterbach, Katja and Chang-Claude, Jenny and Hoffmeister, Michael and Brenner, Hermann and Kirac, Iva and Mato\v{s}evi\'{c}, Petar and Hofer, Philipp and Brezina, Stefanie and Gsur, Andrea and Cheadle, Jeremy P. and Aaltonen, Lauri A. and Tomlinson, Ian and Houlston, Richard S. and Dunlop, Malcolm G.}, year = {2019}, pages = {15}, DOI = {10.1038/s41467-019-09775-w}, chapter = {2154}, keywords = {colorectal cancer}, journal = {Nature communications}, doi = {10.1038/s41467-019-09775-w}, volume = {10}, number = {1}, issn = {2041-1723}, title = {Association analyses identify 31 new risk loci for colorectal cancer susceptibility}, keyword = {colorectal cancer}, chapternumber = {2154} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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