Pregled bibliografske jedinice broj: 1263185
Perimyocarditis as First Manifestation of Systemic Lupus Erythematosus Successfully Treated with Heart Failure and Immunosuppressive Therapy
Perimyocarditis as First Manifestation of Systemic Lupus Erythematosus Successfully Treated with Heart Failure and Immunosuppressive Therapy // Journal of Cardiovascular Development and Disease, 10 (2023), 4; 10040134, 9 doi:10.3390/jcdd10040134 (međunarodna recenzija, članak, stručni)
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Naslov
Perimyocarditis as First Manifestation of Systemic
Lupus Erythematosus Successfully Treated with
Heart Failure and Immunosuppressive Therapy
Autori
Ikić Matijašević, Marina ; Grubić Rotkvić, Petra ; Planinić, Zrinka ; Ikić, Lucija ; Zadro Kordić, Ines ; Galić, Edvard
Izvornik
Journal of Cardiovascular Development and Disease (2308-3425) 10
(2023), 4;
10040134, 9
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni
Ključne riječi
systemic lupus erythematosus ; heart failure ; myocarditis ; pericarditis ; speckle tracking echocardiography ; transthoracic echocardiography ; immunosuppressants ; glucocorticoids ; therapy ; biomarkers
Sažetak
Systemic lupus erythematosus (SLE) myocarditis is presumed to be rare, but associated with adverse outcomes. If SLE diagnosis has not previously been established, its clinical presentation is often unspecific and difficult to recognize. Furthermore, there is a lack of data in the scientific literature regarding myocarditis and its treatment in systemic immune-mediated diseases, leading to its late recognition and undertreatment. We present the case of a young woman whose first lupus manifestations included acute perimyocarditis, among other symptoms and signs that provided clues to the diagnosis of SLE. Transthoracic and speckle tracking echocardiography were helpful in detecting early abnormalities in the myocardial wall thickness and contractility while waiting for cardiac magnetic resonance. Since the patient presented with acute decompensated heart failure (HF), HF treatment was promptly started in parallel with immunosuppressive therapy, with a good response. In the treatment of myocarditis with heart failure, we were guided by the clinical signs, echocardiographic findings, biomarkers of myocardial stress, necrosis, and systemic inflammation, as well as markers of SLE disease activity.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Klinička bolnica "Sveti Duh"
