The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study.

Sušić, L.; Maričić, L.; Šahinović, I.; Kralik, K.; Klobučar, L.; Ćosić, M.; Sušić, T.; Vincelj, J.; Burić, A.; Burić, M.; Lukić, M.

doi:10.3390/ijerph20054433

Pregled bibliografske jedinice broj: 1262557

The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study.

Sušić, L.; Maričić, L.; Šahinović, I.; Kralik, K.; Klobučar, L.; Ćosić, M.; Sušić, T.; Vincelj, J.; Burić, A.; Burić, M.; Lukić, M.

The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study. // International Journal of Environmental Research and Public Health., 20 (2023), 4433, 19 doi:10.3390/ijerph20054433 (recenziran, članak, znanstveni)

CROSBI ID: 1262557 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study.

Autori
Sušić, L. ; Maričić, L. ; Šahinović, I. ; Kralik, K. ; Klobučar, L. ; Ćosić, M. ; Sušić, T. ; Vincelj, J. ; Burić, A. ; Burić, M. ; Lukić, M.

Izvornik
International Journal of Environmental Research and Public Health. (1660-4601) 20 (2023); 4433, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
amino terminal pro-brain natriuretic peptide ; asymmetric dimethylarginine ; cardiovascular diseases ; diastole ; drug therapy ; endothelium ; heart failure ; middle aged ; risk assessment

Sažetak
Abstract: Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk assessed by the Systematic Coronary Risk Evaluation2 (SCORE2) algorithm and HF. Methods: In the period from November 2019 to May 2022, a cross-sectional study that included 178 middle-aged adults was conducted. Transthoracic echocardiography (TTE) was used to assess left ventricular (LV) diastolic and systolic function. ED was assessed using the plasma values of asymmetric dimethylarginine (ADMA) and was determined using the ELISA method. Results: The majority of subjects with LVDD grades 2 and 3 had high/very high SCORE2, developed HF and all were taking medication (p < 0.001). They also had significantly lowest plasma ADMA values (p < 0.001). We found that the reduction of ADMA concentration is influenced by certain groups of drugs, or more significantly, by their combinations (p < 0.001). Conclusions: In our study, we confirmed a positive correlation between LVDD, HF and SCORE2 severity. The results showed a negative correlation between the biomarkers of ED, LVDD severity, HF, and SCORE2, which we believe is due to medication effects.

Izvorni jezik
Engleski

POVEZANOST RADA

Profili:

Lana Maričić (autor)