Naslov
Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis

Autori
Murthy, Vignesh ; Mylonas, Petros ; Carey, Barbara ; Yogarajah, Sangeetha ; Farnell, Damian ; Addison, Owen ; Cook, Richard ; Escudier, Michael ; Diniz-Freitas, Marcio ; Limeres, Jacobo ; Monteiro, Luis ; Silva, Luis ; Fricain, Jean- Cristophe ; Catros, Sylvain ; Fenelon, Mathilde ; Lodi, Giovanni ; Lombardi, Niccolò ; Brailo, Vlaho ; Ariyaratnam, Raj ; López-López, José ; Albuquerque, Rui

Izvornik
Journal of clinical medicine (2077-0383) 11 (2022), 7; 1793, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oral submucous fibrosis ; malignant transformation rate ; oral potentially malignant disorders ; oral cancer ; oral squamous cell carcinoma ; areca nut ; betel nut

Sažetak
Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). A retrospective analysis of medical and dental scientific literature using online indexed databases was conducted for the period 1956 to 2021. The quality of the enrolled studies was assessed by the Newcastle-Ottawa Scale (NOS). A meta-analysis using a random effects model of a single proportion was performed along with statistical tests for heterogeneity. The overall proportion of malignancy across all studies was 0.06 (95% CI, 0.02–0.10), indicating an overall 6% risk of malignant transformation across all studies and cohorts. Sub-group analyses revealed strong differences in proportion of malignancy according to ethnicity/cohort ; Chinese = 0.02 (95% CI 0.01–0.02), Taiwanese = 0.06 (95% CI, 0.03– 0.10), Indian = 0.08 (95% CI, 0.03–0.14) and Pakistani = 0.27 (95% CI 0.25–0.29). Overall, the MTR was 6% ; however, wide heterogeneity of the included studies was noted. Geographic variations in MTR were noted but were not statistically significant. Further studies are required to analyse the difference between cohort groups.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Dentalna medicina

POVEZANOST RADA