Naslov
Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Autori
Jaiswal, Vikash ; Ang, Song Peng ; Lnu, Kriti ; Ishak, Angela ; Pokhrel, Nishan Babu ; Chia, Jia Ee ; Hajra, Adrija ; Biswas, Monodeep ; Matetic, Andrija ; Dhatt, Ravinder ; Mamas, Mamas A.

Izvornik
Journal of Clinical Medicine (2077-0383) 11 (2022), 13; 3799, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
23 PV vaccine ; mortality ; myocardial infarction ; pneumococcal vaccine ; stroke

Sažetak
Various studies have suggested the possible cardiovascular (CV) protective effects of the pneumococcal vaccine (PV). Therefore, we conducted a meta-analysis to assess the association between recipients of PV with mortality and CV outcomes among patients with and without established cardiovascular disease. We performed a systematic literature search in PubMed, Embase, and Sco-pus for studies evaluating the effect of PV on mortality and CV outcomes. A total of 15 studies with 347, 444 patients were included in the meta-analysis: 111, 784 patients received PV (32%) and 235, 660 patients were in the unvaccinated group (68%). Recipients of PV were associated with decreased all-cause mortality (HR, 0.76 (95% CI: 0.66 to 0.87), p < 0.001). PV was associated with a decrease in the incidence of myocardial infarction (MI) (HR, 0.73 (95% CI: 0.56–0.96), p = 0.02), without significant reduction in CV mortality (HR, 0.87 (95% CI: 0.72–1.07), p = 0.18) and stroke (HR, 1.01 (95% CI: 0.93–1.10), p = 0.82). Our study found PV was associated with decreased risk of all-cause mortality and MI. Future RCTs will be necessary to confirm benefits associated with receipt of PV.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA