Naslov
Arrhythmias and sleep related breathing disorders: data from the European Sleep Apnoea Database (ESADA)

Autori
Lombardi, Carolina ; ... ; Đogaš, Zoran ; ... ; Parati, Gianfranco

Kolaboracija
ESADA Collaborators

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Journal of sleep research / - , 2018

Skup
24th Congress of the European Sleep Research Society (ESRS)

Mjesto i datum
Basel, Švicarska, 25.09.2018. - 28.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Arrhythmias ; sleep related breathing disorders

Sažetak
Objectives/Introduction: Cardiac arrhythmias are presumed to be a common problem in patients with OSA, although their true prevalence and gender related differences remain to be determined. The aim of our study was to estimate the prevalence and risk factors for arrhythmias in a large cohort of patients in the context of European Sleep Apnoea Database (ESADA). Methods: A multi‐centric cohort of 22, 169 patients in the ESADA network was evaluated. We estimated the prevalence of cardiac arrhythmias in the whole cohort and separately in four groups: no OSA (AHI<5), mild (AHI = 5–14), moderate (AHI = 15–29) or severe OSA (AHI≥30). We compared clinical and sleep study variables among the groups. Results: The prevalence of arrhythmias in the whole cohort was3.4%, 3.6% among males, 2.8% among females. Patients with arrhythmias were older (61 vs. 52 years), with a similar BMI as com-pared to the patients without arrhythmias (31.8 vs. 31.5 kg/m2).Prevalence of arrhythmias was 1.9%, 3.5%, 3.8% and 3.7% (χ2:p‐value<0.001) in patients with no OSA, mild, moderate or severe OSA, respectively. Additionally, the strongest association between arrhythmias and OSA severity was observed in patients under65 years of age. Interestingly we found peculiar gender differences with a significantly lower prevalence of arrhythmias in females(2.9%) as compared to males (4.2%) in group with moderate OSA(p= 0.032), in particular after 65 years (5.1% vs. 9.0%, p= 0.026). Conclusions: Arrhythmias were common in the ESADA cohort, and an increased severity of OSA was related to an increased risk of arrhythmias, especially in younger individuals. Moreover, female gen-der seems to play a protective role towards arrhythmias in particular in moderate OSA. These results confirm that arrhythmias must be considered in the cardiovascular risk assessment of OSA patients and gender related differences can play a significant role in this association.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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