Naslov
Positional dependency in mild obstructive sleep apnoea in the European Sleep Apnoea Database (ESADA) study

Autori
Bouloukaki, Izolde ; ... ; Đogaš, Zoran ; Schiza, Sophia

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Journal of sleep research / - , 2018

Skup
24th Congress of the European Sleep Research Society (ESRS)

Mjesto i datum
Basel, Švicarska, 25.09.2018. - 28.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mild obstructive sleep apnoea ; positional dependency

Sažetak
Objectives/Introduction: Positional obstructive sleep apnoea (pOSA) is an important sleep apnoea phenotype and seems to be more prevalent in mild OSA patients. The aim of our study was to estimate the prevalence, clinical characteristics and risk factors for pOSA in a group of mild OSA patients of the European Sleep Apnoea Database (ESADA) cohort. Methods: A multi‐centric subsample of 452 mild OSA patients from the ESADA cohort was evaluated. Positional OSA was defined as an overall apnoea‐hypopnea index (AHI)≥5, supine AHI to non‐supine AHI ratio of≥2 and an AHI that normalizes (AHI<5) in the non‐supine posture. We compared clinical and polysomnographic variables between patients with and without pOSA and investigated predictive factors for pOSA using binary logistic regression analysis. Results: Two hundred twenty (49%) of 452 patients fulfilled the pOSA criteria. These patients were significantly younger (46 vs 51, p<0.001) and leaner (BMI 28 vs 30, p= 0.006). Comorbid hyper-tension (24 vs 33%, p= 0.033) and Type 2 diabetes (6 vs 13%p= 0.004) were less prevalent in pOSA compared to non‐pOSA patients. AHI (8.5 vs 10.4), nadir oxygen saturation (87 vs 88%, p= 0.02) and sleep time spent with SaO2<90% (0.2 vs 0.8%, p= 0.004) were lower in pOSA. Negative independent predictors of pOSA in a mild sleep apnoea population were age [odds ratio (95%CI) 0.98 (0.96‐0.99), p= 0.006] and lower AHI [odds ratio (95% CI)0.88 (0.82‐0.94), p<0.001]. Daytime sleepiness reflected by Epworth sleepiness scale score (ESS) did not differ between groups(9.1 vs 9, p= 0.87). Conclusions: Positional OSA is highly prevalent and noted in almost half of our mild OSA patients. Since patients with mild OSA are the prevailing group of OSA patients, positional OSA potentially comprises the vast majority of OSA patients. Furthermore, this pOSA phenotype may reflect the milder form of OSA disease spectrum, including younger patients with a low degree of comorbidities.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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