Naslov
Positional obstructive sleep apnea in the European Sleep Apnoea Database (ESADA) study

Autori
Bouloukaki, Izolde ; Pataka, Athanasia ; Steiropoulos, Paschalis ; Grote, Ludger ; Bonsignore, Marisa ; Hedner, Jan ; Marrone, Oreste ; Basoglu, Ozen ; Verbraecken, Johan ; Lombardi, Carolina ; Parati, Gianfranco ; Đogaš, Zoran ; Schiza, Sophia

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European Respiratory Journal / - : European Respiratory Society, 2018

Skup
28th International Congress of the European Respiratory Society (ERS 2018)

Mjesto i datum
Pariz, Francuska, 15.09.2018. - 19.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
positional obstructive sleep apnea

Sažetak
Background: Positional obstructive sleep apnoea (pOSA) is an important sleep apnea phenotype. However, data on the risk factors and health impact of POSA are limited. Aims and Objectives: To estimate the prevalence and risk factors for pOSA in the European Sleep Apnoea Database (ESADA) cohort and to analyze clinical and polysomnographic characteristics associated with POSA. Methods: A multi-centric subsample of 1084 patients from the ESADA cohort was evaluated. Positional OSA was defined as an overall apnea- hypopnea index (AHI) ≥5, supine AHI to non-supine AHI ratio of ≥2 and an AHI that normalizes (AHI < 5) in the non-supine posture. We compared clinical and polysomnographic variables between patients with and without pOSA and investigated predictive factors for pOSA using binary logistic regression analysis. Results: 27% of patients fulfilled the pOSA criteria. These patients were significantly younger (47 vs 50, p<0.001), leaner (BMI 28 vs 30, p<0.001, neck circumference 39 vs 41, p<0.001). Comorbid hypertension (25 vs 34%, p=0.004), Type 2 diabetes (5 vs 11% p=0.005) and hyperlipidemia (36 vs 48% p<0.001) were less prevalent in pOSA compared to non-pOSA patients. AHI and ODI, were lower in pOSA (10 vs 24 and 5 vs 9, all p<0.001). Sleep architecture was also better preserved in pOSA patients indicated by lower %N1 and higher %N3 (p<0.001). 74% of pOSA patients fulfilled the criteria of mild OSA (overnight AHI 5-<15) compared to 29% in the non-pOSA group. Independent predictors of pOSA were young age and low AHI. Conclusions: pOSA prevalence in our cohort was found lower than previously reported. The pOSA phenotype reflects the mild OSA disease spectrum with a low degree of comorbidities.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA