Naslov
Stable Gastric Pentadecapeptide BPC 157 Counteracts Convulsions Induced by Concomitant Application of Atypical Neuroleptic, SSRI and NSAID, Risperidone, Citalopram and Metamizole in Rats

Autori
Ilic, Spomenko ; Strbe, Sanja ; Zizek, Helena ; Drmic, Domagoj ; Seiwerth, Sven ; Sikiric, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FASEB Journal / - : John Wiley & Sons, 2019, 8227-8227

Skup
Experimental Biology

Mjesto i datum
Orlando (FL), Sjedinjene Američke Države, 06.04.2019. - 09.04.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BPC 157 ; convulsion ; risperidone ; citalopram

Sažetak
We documented that stable gastric pentadecapeptide BPC 157 counteracts convulsions induced by concomitant application of atypical neuroleptic, SSRI and NSAID, risperidone, citalopram and metamizole in rats. BPC 157, LD1 not achieved, was implemented as an anti-ulcer peptide in inflammatory bowel disease trials and now in a multiple sclerosis trial (Curr Pharm Des. 2018 ; 24(18):1990–2001). Previously, BPC 157 counteracts consequences of dopamine (D), receptors blockade (neuroleptics-induced catalepsy, prolonged QT intervals, sphincters dysfunction and gastric lesions), much like over- stimulation (amphetamine acute and chronic disturbances ; much like D-receptors supersensitivity (amphetamine after haloperidol)), nigrostriatal lesions (MPTP Parkinsogenic neurotoxin), D-vesicles depletion (reserpine) (see Sikiric et al., Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications. Curr Neuropharmacol. 2016 ; 14(8):857–865. Review). Similarly, BPC 157 counteracts immobility more than imipramine in depression-models (Porsolt's and chronic unpredictable stress-open field) and induces 5-HT release in particular brain areas (nigrostriatum) when given peripherally, acute and chronically (see Sikiric et al., Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications. Curr Neuropharmacol. 2016 ; 14(8):857–865. Review). Also, BPC 157 counteracts convulsions induced by various convulsants (picrotoxine, strychnine, metrazole, bicuculline) much like either with insulin or with paracetamol (see Sikiric et al., Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications. Curr Neuropharmacol. 2016 ; 14(8):857–865. Review). In this study, we applied (mg/kg) risperidone 2.5 mg/kg, citalopram 2.0 mg/kg and metamizole 2.0 intraperitoneally. Medication (mg/kg), given 15 min before, or immediately after, includes BPC 157(0.01 ; 0, 00001) while control rats received an equivolume of saline (5 mL/kg). Thereafter, at 20 minutes after medication risperidone/citalopram/metamizole rats became markedly sedated. Then, after the next 20 minutes they start with tonic-clonic seizures. The seizure period was lasting for the next 3 hours. Contrarily, either of BPC 157 regimens maintained normal behavior in all rats (Figure. Presentation of risperidone 2.5 mg/kg, citalopram 2.0 mg/kg and metimizole 2.0 mg in rats. Upper. Convulsing control rats. Low. BPC 157 rats normal behavior and counteracted severe convulsions)

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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