Naslov
Lack of association between the 5HT2A receptor polymorphism (T102C) and unipolar affective disorder in a multicentric European study.

Autori
Oswald, Pierre ; Souery, Daniel ; Massat, Isabelle ; Del-Favero, Jurgen ; Linotte, Sylvi ; , Papadimitriou, George ; Dikeos, Dimitris ; , Kaneva, Radka ; Milanova, Vibra ; Oruc, Liliana ; Ivezic, Slađana ; , Serretti, Alesasandro, ; Lilli, Roberta ; Van Broeckhoven, Cristine ; Mendlewicz, Julien

Izvornik
European neuropsychopharmacology (0924-977X) 13 (2003); 365-368

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5HT2A receptor, unipolar affective disorder, multicentric European study

Sažetak
We report here a case-control association study with T102C polymorphism in the serotonin 2A receptor gene (HTR2A) in patients affected by unipolar affective disorder (UPAD) and in controls. A total of 284 subjects were genotyped (142 UPAD and 142 controls). All subjects were interviewed using standard diagnostic interviews and matched. A homogenous population of unipolar patients with suicidal attempt was identified. Conditional logistic regression was applied. No association of the HTR2A polymorphism was found in the overall sample of 142 UPAD-control pairs regarding allele and genotype frequencies (P=0.36 and P=0.52 respectively) and homo-heterozygote distributions (P=0.91). This study confirms, in a multicentric European sample, the earlier observations that the T102C HTR2A polymorphism is not associated with UPAD. Nevertheless, a type 2 statistical error cannot be excluded. Therefore, to exclude the implication of HTR2A in UPAD, this result must be replicated in larger samples and in other populations using the transmission disequilibrium test and different polymorphisms around HTR2A.

Izvorni jezik
Engleski

POVEZANOST RADA