Naslov
Prognostic value of Ki-67 and ENSAT stage on recurrence-free survival and overall survival in patients with adrenocortical carcinoma

Autori
Kraljevic, Ivana ; Knezevic, Nikola ; Kakrigi, Luka ; Kakarigi, Marko ; Dusek, Tina ; Solak, Mirsala ; Skoric, Polovina Tanja ; Balasko, Annemarie ; Zibar, Tomšić Karin ; Alduk, Ana Marija ; Kastelan, Darko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
22nd European Congress of Endocrinology

Mjesto i datum
Online, 05.09.2020. - 09.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
adrenocortical carcinoma

Sažetak
Background: The adrenocortical carcinoma (ACC) is a rare malignancy with poor outcomes and overall survival of less than 40%. Different prognostic factors were evaluated in patients with ACC. We analyzed overall survival (OS) and recurrence-free survival (RFS) in patients with ACC depending on Ki-67 and ENSAT staging. Methods: We performed a retrospective study on 62 ACC patients treated at the Croatian Referral Center for adrenal gland disorders from 2005 to 2019. Six patients (10%) had ENSAT stage I disease, 30 patients (48%) stage II, 14 patients (23%) stage III and 12 patients (19%) stage IV. RFS was analyzed in 47 patients with the ACC ENSAT stage I-III and R0 resection. Based on Ki-67 patients were stratified in two groups: Ki-67 ≤ 10% and Ki-67 > 10%. Results: The mean age of patients was 49.1 ± 15.5 years and 70.9% were females. During the study, 15 patients died of whom 10 deaths were related to ACC. The mean OS was 83.3 ± 14.3 months, 153.7 ± 11.3 months, 77.1 ± 14.5 months and 19.7 ± 4.9 months for ENSAT stage I, II, III, and IV, respectively (P < 0.001). Disease recurrence was observed in 9 patients (19%) of whom two patients had Ki-67 ≤ 10%.The mean RFS was 68.3 ± 9.5 months, 109.9 ± 9.4 months and 82.4 ± 16.4 months for ENSAT stage I, II and III, respectively (P = 0.916). Ki-67>10% was associated with poorer survival (P = 0.04). Conclusion: Our data confirmed that the ENSAT stage and Ki-67 are major predictors of ACC patient’s survival. However, in our cohort of patients, Ki-67 has not been associated with the ACC recurrence.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA