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Pregled bibliografske jedinice broj: 1259791

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

(UKGPCS collaborators ; APCB (Australian Prostate Cancer BioResource) ; NC-LA PCaP Investigators ; The IMPACT Study Steering Committee and Collaborators, ; Canary PASS Investigators ; The Profile Study Steering Committee ; The PRACTICAL Consortium) Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan; Thompson, Wesley K.; Martinez, Maria Elena; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Schleutker, Johanna; Pashayan, Nora et al.
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations // Nature communications, 12 (2021), 1; 1236, 9 doi:10.1038/s41467-021-21287-0 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1259791 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
(Polygenic hazard score is associated with prostate cancer in multi-ethnic populations)

Autori
Huynh-Le, Minh-Phuong ; Fan, Chun Chieh ; Karunamuni, Roshan ; Thompson, Wesley K. ; Martinez, Maria Elena ; Eeles, Rosalind A. ; Kote-Jarai, Zsofia ; Muir, Kenneth ; Schleutker, Johanna ; Pashayan, Nora ; Batra, Jyotsna ; Grönberg, Henrik ; Neal, David E. ; Donovan, Jenny L. ; Hamdy, Freddie C. ; Martin, Richard M. ; Nielsen, Sune F. ; Nordestgaard, Børge G. ; Wiklund, Fredrik ; Tangen, Catherine M. ; Giles, Graham G. ; Wolk, Alicja ; Albanes, Demetrius ; Travis, Ruth C. ; Blot, William J. ; Zheng, Wei ; Sanderson, Maureen ; Stanford, Janet L. ; Mucci, Lorelei A. ; West, Catharine M. L. ; Kibel, Adam S. ; Cussenot, Olivier ; Berndt, Sonja I. ; Koutros, Stella ; Sørensen, Karina Dalsgaard ; Cybulski, Cezary ; Grindedal, Eli Marie ; Menegaux, Florence ; Khaw, Kay-Tee ; Park, Jong Y. ; Ingles, Sue A. ; Maier, Christiane ; Hamilton, Robert J. ; Thibodeau, Stephen N. ; Rosenstein, Barry S. ; Lu, Yong-Jie ; Watya, Stephen ; Vega, Ana ; Kogevinas, Manolis ; Penney, Kathryn L. ; Huff, Chad ; Teixeira, Manuel R. ; Multigner, Luc ; Leach, Robin J. ; Cannon-Albright, Lisa ; Brenner, Hermann ; John, Esther M. ; Kaneva, Radka ; Logothetis, Christopher J. ; Neuhausen, Susan L. ; De Ruyck, Kim ; Pandha, Hardev ; Razack, Azad ; Newcomb, Lisa F. ; Fowke, Jay H. ; Gamulin, Marija ; Usmani, Nawaid ; Claessens, Frank ; Gago-Dominguez, Manuela ; Townsend, Paul A. ; Bush, William S. ; Roobol, Monique J. ; Parent, Marie-Élise ; Hu, Jennifer J. ; Mills, Ian G. ; Andreassen, Ole A. ; Dale, Anders M. ; Seibert, Tyler M.

Kolaboracija
UKGPCS collaborators ; APCB (Australian Prostate Cancer BioResource) ; NC-LA PCaP Investigators ; The IMPACT Study Steering Committee and Collaborators, ; Canary PASS Investigators ; The Profile Study Steering Committee ; The PRACTICAL Consortium

Izvornik
Nature communications (2041-1723) 12 (2021), 1; 1236, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
polygenic hazard score (PHS1) ; prostate cancer

Sažetak
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80, 491 men (49, 916 cases, 30, 575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate- cancer-specific death. Associations with cancer are significant within European (n = 71, 856), Asian (n = 2, 382), and African (n = 6, 253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate- cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk- stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Marija Gamulin (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(UKGPCS collaborators ; APCB (Australian Prostate Cancer BioResource) ; NC-LA PCaP Investigators ; The IMPACT Study Steering Committee and Collaborators, ; Canary PASS Investigators ; The Profile Study Steering Committee ; The PRACTICAL Consortium) Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan; Thompson, Wesley K.; Martinez, Maria Elena; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Schleutker, Johanna; Pashayan, Nora et al.
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations // Nature communications, 12 (2021), 1; 1236, 9 doi:10.1038/s41467-021-21287-0 (međunarodna recenzija, članak, znanstveni)
(UKGPCS collaborators ; APCB (Australian Prostate Cancer BioResource) ; NC-LA PCaP Investigators ; The IMPACT Study Steering Committee and Collaborators, ; Canary PASS Investigators ; The Profile Study Steering Committee ; The PRACTICAL Consortium) (UKGPCS collaborators, APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, The IMPACT Study Steering Committee and Collaborators, ., Canary PASS Investigators, The Profile Study Steering Committee, The PRACTICAL Consortium) Huynh-Le, M., Fan, C., Karunamuni, R., Thompson, W., Martinez, M., Eeles, R., Kote-Jarai, Z., Muir, K., Schleutker, J. & Pashayan, N. (2021) Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. Nature communications, 12 (1), 1236, 9 doi:10.1038/s41467-021-21287-0.
@article{article, author = {Huynh-Le, Minh-Phuong and Fan, Chun Chieh and Karunamuni, Roshan and Thompson, Wesley K. and Martinez, Maria Elena and Eeles, Rosalind A. and Kote-Jarai, Zsofia and Muir, Kenneth and Schleutker, Johanna and Pashayan, Nora and Batra, Jyotsna and Gr\"{o}nberg, Henrik and Neal, David E. and Donovan, Jenny L. and Hamdy, Freddie C. and Martin, Richard M. and Nielsen, Sune F. and Nordestgaard, B\orge G. and Wiklund, Fredrik and Tangen, Catherine M. and Giles, Graham G. and Wolk, Alicja and Albanes, Demetrius and Travis, Ruth C. and Blot, William J. and Zheng, Wei and Sanderson, Maureen and Stanford, Janet L. and Mucci, Lorelei A. and West, Catharine M. L. and Kibel, Adam S. and Cussenot, Olivier and Berndt, Sonja I. and Koutros, Stella and S\orensen, Karina Dalsgaard and Cybulski, Cezary and Grindedal, Eli Marie and Menegaux, Florence and Khaw, Kay-Tee and Park, Jong Y. and Ingles, Sue A. and Maier, Christiane and Hamilton, Robert J. and Thibodeau, Stephen N. and Rosenstein, Barry S. and Lu, Yong-Jie and Watya, Stephen and Vega, Ana and Kogevinas, Manolis and Penney, Kathryn L. and Huff, Chad and Teixeira, Manuel R. and Multigner, Luc and Leach, Robin J. and Cannon-Albright, Lisa and Brenner, Hermann and John, Esther M. and Kaneva, Radka and Logothetis, Christopher J. and Neuhausen, Susan L. and De Ruyck, Kim and Pandha, Hardev and Razack, Azad and Newcomb, Lisa F. and Fowke, Jay H. and Gamulin, Marija and Usmani, Nawaid and Claessens, Frank and Gago-Dominguez, Manuela and Townsend, Paul A. and Bush, William S. and Roobol, Monique J. and Parent, Marie-\'{E}lise and Hu, Jennifer J. and Mills, Ian G. and Andreassen, Ole A. and Dale, Anders M. and Seibert, Tyler M.}, year = {2021}, pages = {9}, DOI = {10.1038/s41467-021-21287-0}, chapter = {1236}, keywords = {polygenic hazard score (PHS1), prostate cancer}, journal = {Nature communications}, doi = {10.1038/s41467-021-21287-0}, volume = {12}, number = {1}, issn = {2041-1723}, title = {Polygenic hazard score is associated with prostate cancer in multi-ethnic populations}, keyword = {polygenic hazard score (PHS1), prostate cancer}, chapternumber = {1236} }
@article{article, author = {Huynh-Le, Minh-Phuong and Fan, Chun Chieh and Karunamuni, Roshan and Thompson, Wesley K. and Martinez, Maria Elena and Eeles, Rosalind A. and Kote-Jarai, Zsofia and Muir, Kenneth and Schleutker, Johanna and Pashayan, Nora and Batra, Jyotsna and Gr\"{o}nberg, Henrik and Neal, David E. and Donovan, Jenny L. and Hamdy, Freddie C. and Martin, Richard M. and Nielsen, Sune F. and Nordestgaard, B\orge G. and Wiklund, Fredrik and Tangen, Catherine M. and Giles, Graham G. and Wolk, Alicja and Albanes, Demetrius and Travis, Ruth C. and Blot, William J. and Zheng, Wei and Sanderson, Maureen and Stanford, Janet L. and Mucci, Lorelei A. and West, Catharine M. L. and Kibel, Adam S. and Cussenot, Olivier and Berndt, Sonja I. and Koutros, Stella and S\orensen, Karina Dalsgaard and Cybulski, Cezary and Grindedal, Eli Marie and Menegaux, Florence and Khaw, Kay-Tee and Park, Jong Y. and Ingles, Sue A. and Maier, Christiane and Hamilton, Robert J. and Thibodeau, Stephen N. and Rosenstein, Barry S. and Lu, Yong-Jie and Watya, Stephen and Vega, Ana and Kogevinas, Manolis and Penney, Kathryn L. and Huff, Chad and Teixeira, Manuel R. and Multigner, Luc and Leach, Robin J. and Cannon-Albright, Lisa and Brenner, Hermann and John, Esther M. and Kaneva, Radka and Logothetis, Christopher J. and Neuhausen, Susan L. and De Ruyck, Kim and Pandha, Hardev and Razack, Azad and Newcomb, Lisa F. and Fowke, Jay H. and Gamulin, Marija and Usmani, Nawaid and Claessens, Frank and Gago-Dominguez, Manuela and Townsend, Paul A. and Bush, William S. and Roobol, Monique J. and Parent, Marie-\'{E}lise and Hu, Jennifer J. and Mills, Ian G. and Andreassen, Ole A. and Dale, Anders M. and Seibert, Tyler M.}, year = {2021}, pages = {9}, DOI = {10.1038/s41467-021-21287-0}, chapter = {1236}, keywords = {polygenic hazard score (PHS1), prostate cancer}, journal = {Nature communications}, doi = {10.1038/s41467-021-21287-0}, volume = {12}, number = {1}, issn = {2041-1723}, title = {Polygenic hazard score is associated with prostate cancer in multi-ethnic populations}, keyword = {polygenic hazard score (PHS1), prostate cancer}, chapternumber = {1236} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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