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Pregled bibliografske jedinice broj: 1259775

Identification of 22 susceptibility loci associated with testicular germ cell tumors

(The Testicular Cancer Consortium) Pluta, John; Pyle, Louise C.; Nead, Kevin T.; Wilf, Rona; Li, Mingyao; Mitra, Nandita; Weathers, Benita; D’Andrea, Kurt; Almstrup, Kristian; Anson-Cartwright, Lynn et al.
Identification of 22 susceptibility loci associated with testicular germ cell tumors // Nature communications, 12 (2021), 1; 4487, 13 doi:10.1038/s41467-021-24334-y (međunarodna recenzija, članak, znanstveni)

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Naslov
Identification of 22 susceptibility loci associated with testicular germ cell tumors
(Identification of 22 susceptibility loci associated with testicular germ cell tumors)

Autori
Pluta, John ; Pyle, Louise C. ; Nead, Kevin T. ; Wilf, Rona ; Li, Mingyao ; Mitra, Nandita ; Weathers, Benita ; D’Andrea, Kurt ; Almstrup, Kristian ; Anson-Cartwright, Lynn ; Benitez, Javier ; Brown, Christopher D. ; Chanock, Stephen ; Chen, Chu ; Cortessis, Victoria K. ; Ferlin, Alberto ; Foresta, Carlo ; Gamulin, Marija ; Gietema, Jourik A. ; Grasso, Chiara ; Greene, Mark H. ; Grotmol, Tom ; Hamilton, Robert J. ; Haugen, Trine B. ; Hauser, Russ ; Hildebrandt, Michelle A. T. ; Johnson, Matthew E. ; Karlsson, Robert ; Kiemeney, Lambertus A. ; Lessel, Davor ; Lothe, Ragnhild A. ; Loud, Jennifer T. ; Loveday, Chey ; Martin-Gimeno, Paloma ; Meijer, Coby ; Nsengimana, Jérémie ; Quinn, David I. ; Rafnar, Thorunn ; Ramdas, Shweta ; Richiardi, Lorenzo ; Skotheim, Rolf I. ; Stefansson, Kari ; Turnbull, Clare ; Vaughn, David J. ; Wiklund, Fredrik ; Wu, Xifeng ; Yang, Daphne ; Zheng, Tongzhang ; Wells, Andrew D. ; Grant, Struan F. A. ; Rajpert-De Meyts, Ewa ; Schwartz, Stephen M. ; Bishop, D. Timothy ; McGlynn, Katherine A. ; Kanetsky, Peter A. ; Nathanson, Katherine L. ; Kubisch, Christian

Kolaboracija
The Testicular Cancer Consortium

Izvornik
Nature communications (2041-1723) 12 (2021), 1; 4487, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
testicular germ cell tumors (TGCT)

Sažetak
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10, 156 and 179, 683 men with and without TGCT, respectively, for a genome-wide association study. This meta- analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men with a polygenic risk score (PRS) in the 95th percentile have a 6.8-fold increased risk of TGCT compared to men with median scores. Among men with independent TGCT risk factors such as cryptorchidism, the PRS may guide screening decisions with the goal of reducing treatment-related complications causing long-term morbidity in survivors. These findings emphasize the interconnected nature of two known pathways that promote TGCT susceptibility: male germ cell development within its somatic niche and regulation of chromosomal division and structure, and implicate an additional biological pathway, mRNA translation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Marija Gamulin (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(The Testicular Cancer Consortium) Pluta, John; Pyle, Louise C.; Nead, Kevin T.; Wilf, Rona; Li, Mingyao; Mitra, Nandita; Weathers, Benita; D’Andrea, Kurt; Almstrup, Kristian; Anson-Cartwright, Lynn et al.
Identification of 22 susceptibility loci associated with testicular germ cell tumors // Nature communications, 12 (2021), 1; 4487, 13 doi:10.1038/s41467-021-24334-y (međunarodna recenzija, članak, znanstveni)
(The Testicular Cancer Consortium) (The Testicular Cancer Consortium) Pluta, J., Pyle, L., Nead, K., Wilf, R., Li, M., Mitra, N., Weathers, B., D’Andrea, K., Almstrup, K. & Anson-Cartwright, L. (2021) Identification of 22 susceptibility loci associated with testicular germ cell tumors. Nature communications, 12 (1), 4487, 13 doi:10.1038/s41467-021-24334-y.
@article{article, author = {Pluta, John and Pyle, Louise C. and Nead, Kevin T. and Wilf, Rona and Li, Mingyao and Mitra, Nandita and Weathers, Benita and D’Andrea, Kurt and Almstrup, Kristian and Anson-Cartwright, Lynn and Benitez, Javier and Brown, Christopher D. and Chanock, Stephen and Chen, Chu and Cortessis, Victoria K. and Ferlin, Alberto and Foresta, Carlo and Gamulin, Marija and Gietema, Jourik A. and Grasso, Chiara and Greene, Mark H. and Grotmol, Tom and Hamilton, Robert J. and Haugen, Trine B. and Hauser, Russ and Hildebrandt, Michelle A. T. and Johnson, Matthew E. and Karlsson, Robert and Kiemeney, Lambertus A. and Lessel, Davor and Lothe, Ragnhild A. and Loud, Jennifer T. and Loveday, Chey and Martin-Gimeno, Paloma and Meijer, Coby and Nsengimana, J\'{e}r\'{e}mie and Quinn, David I. and Rafnar, Thorunn and Ramdas, Shweta and Richiardi, Lorenzo and Skotheim, Rolf I. and Stefansson, Kari and Turnbull, Clare and Vaughn, David J. and Wiklund, Fredrik and Wu, Xifeng and Yang, Daphne and Zheng, Tongzhang and Wells, Andrew D. and Grant, Struan F. A. and Rajpert-De Meyts, Ewa and Schwartz, Stephen M. and Bishop, D. Timothy and McGlynn, Katherine A. and Kanetsky, Peter A. and Nathanson, Katherine L. and Kubisch, Christian}, year = {2021}, pages = {13}, DOI = {10.1038/s41467-021-24334-y}, chapter = {4487}, keywords = {testicular germ cell tumors (TGCT)}, journal = {Nature communications}, doi = {10.1038/s41467-021-24334-y}, volume = {12}, number = {1}, issn = {2041-1723}, title = {Identification of 22 susceptibility loci associated with testicular germ cell tumors}, keyword = {testicular germ cell tumors (TGCT)}, chapternumber = {4487} }
@article{article, author = {Pluta, John and Pyle, Louise C. and Nead, Kevin T. and Wilf, Rona and Li, Mingyao and Mitra, Nandita and Weathers, Benita and D’Andrea, Kurt and Almstrup, Kristian and Anson-Cartwright, Lynn and Benitez, Javier and Brown, Christopher D. and Chanock, Stephen and Chen, Chu and Cortessis, Victoria K. and Ferlin, Alberto and Foresta, Carlo and Gamulin, Marija and Gietema, Jourik A. and Grasso, Chiara and Greene, Mark H. and Grotmol, Tom and Hamilton, Robert J. and Haugen, Trine B. and Hauser, Russ and Hildebrandt, Michelle A. T. and Johnson, Matthew E. and Karlsson, Robert and Kiemeney, Lambertus A. and Lessel, Davor and Lothe, Ragnhild A. and Loud, Jennifer T. and Loveday, Chey and Martin-Gimeno, Paloma and Meijer, Coby and Nsengimana, J\'{e}r\'{e}mie and Quinn, David I. and Rafnar, Thorunn and Ramdas, Shweta and Richiardi, Lorenzo and Skotheim, Rolf I. and Stefansson, Kari and Turnbull, Clare and Vaughn, David J. and Wiklund, Fredrik and Wu, Xifeng and Yang, Daphne and Zheng, Tongzhang and Wells, Andrew D. and Grant, Struan F. A. and Rajpert-De Meyts, Ewa and Schwartz, Stephen M. and Bishop, D. Timothy and McGlynn, Katherine A. and Kanetsky, Peter A. and Nathanson, Katherine L. and Kubisch, Christian}, year = {2021}, pages = {13}, DOI = {10.1038/s41467-021-24334-y}, chapter = {4487}, keywords = {testicular germ cell tumors (TGCT)}, journal = {Nature communications}, doi = {10.1038/s41467-021-24334-y}, volume = {12}, number = {1}, issn = {2041-1723}, title = {Identification of 22 susceptibility loci associated with testicular germ cell tumors}, keyword = {testicular germ cell tumors (TGCT)}, chapternumber = {4487} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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