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Pregled bibliografske jedinice broj: 1259764

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

(Australian Prostate Cancer BioResource (APCB) ; The IMPACT Study ; Canary PASS Investigators ; Breast and Prostate Cancer Cohort Consortium (BPC3) ; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium ; Cancer of the Prostate in Sweden (CAPS) ; Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS) ; The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium) Schumacher, Fredrick R.; The Profile Study; Al Olama, Ali Amin; Berndt, Sonja I.; Benlloch, Sara; Ahmed, Mahbubl; Saunders, Edward J.; Dadaev, Tokhir; Leongamornlert, Daniel; Anokian, Ezequiel et al.
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci // Nature genetics, 50 (2018), 7; 928-936 doi:10.1038/s41588-018-0142-8 (međunarodna recenzija, pismo, stručni)

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Naslov
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Autori
Schumacher, Fredrick R. ; The Profile Study ; Al Olama, Ali Amin ; Berndt, Sonja I. ; Benlloch, Sara ; Ahmed, Mahbubl ; Saunders, Edward J. ; Dadaev, Tokhir ; Leongamornlert, Daniel ; Anokian, Ezequiel ; Cieza-Borrella, Clara ; Goh, Chee ; Brook, Mark N. ; Sheng, Xin ; Fachal, Laura ; Dennis, Joe ; Tyrer, Jonathan ; Muir, Kenneth ; Lophatananon, Artitaya ; Stevens, Victoria L. ; Gapstur, Susan M. ; Carter, Brian D. ; Tangen, Catherine M. ; Goodman, Phyllis J. ; Thompson, Ian M. ; Batra, Jyotsna ; Chambers, Suzanne ; Moya, Leire ; Clements, Judith ; Horvath, Lisa ; Tilley, Wayne ; Risbridger, Gail P. ; Gronberg, Henrik ; Aly, Markus ; Nordström, Tobias ; Pharoah, Paul ; Pashayan, Nora ; Schleutker, Johanna ; Tammela, Teuvo L. J. ; Sipeky, Csilla ; Auvinen, Anssi ; Albanes, Demetrius ; Weinstein, Stephanie ; Wolk, Alicja ; Håkansson, Niclas ; West, Catharine M. L. ; Dunning, Alison M. ; Burnet, Neil ; Mucci, Lorelei A. ; Giovannucci, Edward ; Andriole, Gerald L. ; Cussenot, Olivier ; Cancel- Tassin, Géraldine ; Koutros, Stella ; Beane Freeman, Laura E. ; Sorensen, Karina Dalsgaard ; Orntoft, Torben Falck ; Borre, Michael ; Maehle, Lovise ; Grindedal, Eli Marie ; Neal, David E. ; Donovan, Jenny L. ; Hamdy, Freddie C. ; Martin, Richard M. ; Travis, Ruth C. ; Key, Tim J. ; Hamilton, Robert J. ; Fleshner, Neil E. ; Finelli, Antonio ; Ingles, Sue Ann ; Stern, Mariana C. ; Rosenstein, Barry S. ; Kerns, Sarah L. ; Ostrer, Harry ; Lu, Yong-Jie ; Zhang, Hong-Wei ; Feng, Ninghan ; Mao, Xueying ; Guo, Xin ; Wang, Guomin ; Sun, Zan ; Giles, Graham G. ; Southey, Melissa C. ; MacInnis, Robert J. ; FitzGerald, Liesel M. ; Kibel, Adam S. ; Drake, Bettina F. ; Vega, Ana ; Gómez-Caamaño, Antonio ; Szulkin, Robert ; Eklund, Martin ; Kogevinas, Manolis ; Llorca, Javier ; Castaño-Vinyals, Gemma ; Penney, Kathryn L. ; Stampfer, Meir ; Park, Jong Y. ; Sellers, Thomas A. ; Lin, Hui-Yi ; Stanford, Janet L. ; Cybulski, Cezary ; Wokolorczyk, Dominika ; Lubinski, Jan ; Ostrander, Elaine A. ; Geybels, Milan S. ; Nordestgaard, Børge G. ; Nielsen, Sune F. ; Weischer, Maren ; Bisbjerg, Rasmus ; Røder, Martin Andreas ; Iversen, Peter ; Brenner, Hermann ; Cuk, Katarina ; Holleczek, Bernd ; Maier, Christiane ; Luedeke, Manuel ; Schnoeller, Thomas ; Kim, Jeri ; Logothetis, Christopher J. ; John, Esther M. ; Teixeira, Manuel R. ; Paulo, Paula ; Cardoso, Marta ; Neuhausen, Susan L. ; Steele, Linda ; Ding, Yuan Chun ; De Ruyck, Kim ; De Meerleer, Gert ; Ost, Piet ; Razack, Azad ; Lim, Jasmine ; Teo, Soo-Hwang ; Lin, Daniel W. ; Newcomb, Lisa F. ; Lessel, Davor ; Gamulin, Marija ; Kuliš, Tomislav ; Kaneva, Radka ; Usmani, Nawaid ; Singhal, Sandeep ; Slavov, Chavdar ; Mitev, Vanio ; Parliament, Matthew ; Claessens, Frank ; Joniau, Steven ; Van den Broeck, Thomas ; Larkin, Samantha ; Townsend, Paul A. ; Aukim-Hastie, Claire ; Gago-Dominguez, Manuela ; Castelao, Jose Esteban ; Martinez, Maria Elena ; Roobol, Monique J. ; Jenster, Guido ; van Schaik, Ron H. N. ; Menegaux, Florence ; Truong, Thérèse ; Koudou, Yves Akoli ; Xu, Jianfeng ; Khaw, Kay-Tee ; Cannon-Albright, Lisa ; Pandha, Hardev ; Michael, Agnieszka ; Thibodeau, Stephen N. ; McDonnell, Shannon K. ; Schaid, Daniel J. ; Lindstrom, Sara ; Turman, Constance ; Ma, Jing ; Hunter, David J. ; Riboli, Elio ; Siddiq, Afshan ; Canzian, Federico ; Kolonel, Laurence N. ; Le Marchand, Loic ; Hoover, Robert N. ; Machiela, Mitchell J. ; Cui, Zuxi ; Kraft, Peter ; Amos, Christopher I. ; Conti, David V. ; Easton, Douglas F. ; Wiklund, Fredrik ; Chanock, Stephen J. ; Henderson, Brian E. ; Kote-Jarai, Zsofia ; Haiman, Christopher A. ; Eeles, Rosalind A.

Kolaboracija
Australian Prostate Cancer BioResource (APCB) ; The IMPACT Study ; Canary PASS Investigators ; Breast and Prostate Cancer Cohort Consortium (BPC3) ; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium ; Cancer of the Prostate in Sweden (CAPS) ; Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS) ; The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium

Izvornik
Nature genetics (1061-4036) 50 (2018), 7; 928-936

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, stručni

Ključne riječi
prostate cancer (PrCa)-susceptibility loci

Sažetak
Genome-wide association studies (GWAS) and fine- mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high- density array of 46, 939 PrCa cases and 27, 910 controls of European ancestry with previously genotyped data of 32, 255 PrCa cases and 33, 202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10- 8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16 ; P = 8.2 × 10-9 ; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06 ; P = 2.3 × 10-9 ; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69 ; 95% confidence interval (CI): 2.55- 2.82) and first percentile (relative risk = 5.71 ; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Marija Gamulin (autor)

Avatar Url Tomislav Kuliš (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(Australian Prostate Cancer BioResource (APCB) ; The IMPACT Study ; Canary PASS Investigators ; Breast and Prostate Cancer Cohort Consortium (BPC3) ; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium ; Cancer of the Prostate in Sweden (CAPS) ; Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS) ; The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium) Schumacher, Fredrick R.; The Profile Study; Al Olama, Ali Amin; Berndt, Sonja I.; Benlloch, Sara; Ahmed, Mahbubl; Saunders, Edward J.; Dadaev, Tokhir; Leongamornlert, Daniel; Anokian, Ezequiel et al.
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci // Nature genetics, 50 (2018), 7; 928-936 doi:10.1038/s41588-018-0142-8 (međunarodna recenzija, pismo, stručni)
(Australian Prostate Cancer BioResource (APCB) ; The IMPACT Study ; Canary PASS Investigators ; Breast and Prostate Cancer Cohort Consortium (BPC3) ; The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium ; Cancer of the Prostate in Sweden (CAPS) ; Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS) ; The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium) (Australian Prostate Cancer BioResource (APCB), The IMPACT Study, Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Cancer of the Prostate in Sweden (CAPS), Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium) Schumacher, F., The Profile Study, Al Olama, A., Berndt, S., Benlloch, S., Ahmed, M., Saunders, E., Dadaev, T., Leongamornlert, D. & Anokian, E. (2018) Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nature genetics, 50 (7), 928-936 doi:10.1038/s41588-018-0142-8.
@article{article, author = {Schumacher, Fredrick R. and Al Olama, Ali Amin and Berndt, Sonja I. and Benlloch, Sara and Ahmed, Mahbubl and Saunders, Edward J. and Dadaev, Tokhir and Leongamornlert, Daniel and Anokian, Ezequiel and Cieza-Borrella, Clara and Goh, Chee and Brook, Mark N. and Sheng, Xin and Fachal, Laura and Dennis, Joe and Tyrer, Jonathan and Muir, Kenneth and Lophatananon, Artitaya and Stevens, Victoria L. and Gapstur, Susan M. and Carter, Brian D. and Tangen, Catherine M. and Goodman, Phyllis J. and Thompson, Ian M. and Batra, Jyotsna and Chambers, Suzanne and Moya, Leire and Clements, Judith and Horvath, Lisa and Tilley, Wayne and Risbridger, Gail P. and Gronberg, Henrik and Aly, Markus and Nordstr\"{o}m, Tobias and Pharoah, Paul and Pashayan, Nora and Schleutker, Johanna and Tammela, Teuvo L. J. and Sipeky, Csilla and Auvinen, Anssi and Albanes, Demetrius and Weinstein, Stephanie and Wolk, Alicja and H\aakansson, Niclas and West, Catharine M. L. and Dunning, Alison M. and Burnet, Neil and Mucci, Lorelei A. and Giovannucci, Edward and Andriole, Gerald L. and Cussenot, Olivier and Cancel- Tassin, G\'{e}raldine and Koutros, Stella and Beane Freeman, Laura E. and Sorensen, Karina Dalsgaard and Orntoft, Torben Falck and Borre, Michael and Maehle, Lovise and Grindedal, Eli Marie and Neal, David E. and Donovan, Jenny L. and Hamdy, Freddie C. and Martin, Richard M. and Travis, Ruth C. and Key, Tim J. and Hamilton, Robert J. and Fleshner, Neil E. and Finelli, Antonio and Ingles, Sue Ann and Stern, Mariana C. and Rosenstein, Barry S. and Kerns, Sarah L. and Ostrer, Harry and Lu, Yong-Jie and Zhang, Hong-Wei and Feng, Ninghan and Mao, Xueying and Guo, Xin and Wang, Guomin and Sun, Zan and Giles, Graham G. and Southey, Melissa C. and MacInnis, Robert J. and FitzGerald, Liesel M. and Kibel, Adam S. and Drake, Bettina F. and Vega, Ana and G\'{o}mez-Caama\~{n}o, Antonio and Szulkin, Robert and Eklund, Martin and Kogevinas, Manolis and Llorca, Javier and Casta\~{n}o-Vinyals, Gemma and Penney, Kathryn L. and Stampfer, Meir and Park, Jong Y. and Sellers, Thomas A. and Lin, Hui-Yi and Stanford, Janet L. and Cybulski, Cezary and Wokolorczyk, Dominika and Lubinski, Jan and Ostrander, Elaine A. and Geybels, Milan S. and Nordestgaard, B\orge G. and Nielsen, Sune F. and Weischer, Maren and Bisbjerg, Rasmus and R\oder, Martin Andreas and Iversen, Peter and Brenner, Hermann and Cuk, Katarina and Holleczek, Bernd and Maier, Christiane and Luedeke, Manuel and Schnoeller, Thomas and Kim, Jeri and Logothetis, Christopher J. and John, Esther M. and Teixeira, Manuel R. and Paulo, Paula and Cardoso, Marta and Neuhausen, Susan L. and Steele, Linda and Ding, Yuan Chun and De Ruyck, Kim and De Meerleer, Gert and Ost, Piet and Razack, Azad and Lim, Jasmine and Teo, Soo-Hwang and Lin, Daniel W. and Newcomb, Lisa F. and Lessel, Davor and Gamulin, Marija and Kuli\v{s}, Tomislav and Kaneva, Radka and Usmani, Nawaid and Singhal, Sandeep and Slavov, Chavdar and Mitev, Vanio and Parliament, Matthew and Claessens, Frank and Joniau, Steven and Van den Broeck, Thomas and Larkin, Samantha and Townsend, Paul A. and Aukim-Hastie, Claire and Gago-Dominguez, Manuela and Castelao, Jose Esteban and Martinez, Maria Elena and Roobol, Monique J. and Jenster, Guido and van Schaik, Ron H. N. and Menegaux, Florence and Truong, Th\'{e}r\`{e}se and Koudou, Yves Akoli and Xu, Jianfeng and Khaw, Kay-Tee and Cannon-Albright, Lisa and Pandha, Hardev and Michael, Agnieszka and Thibodeau, Stephen N. and McDonnell, Shannon K. and Schaid, Daniel J. and Lindstrom, Sara and Turman, Constance and Ma, Jing and Hunter, David J. and Riboli, Elio and Siddiq, Afshan and Canzian, Federico and Kolonel, Laurence N. and Le Marchand, Loic and Hoover, Robert N. and Machiela, Mitchell J. and Cui, Zuxi and Kraft, Peter and Amos, Christopher I. and Conti, David V. and Easton, Douglas F. and Wiklund, Fredrik and Chanock, Stephen J. and Henderson, Brian E. and Kote-Jarai, Zsofia and Haiman, Christopher A. and Eeles, Rosalind A.}, year = {2018}, pages = {928-936}, DOI = {10.1038/s41588-018-0142-8}, keywords = {prostate cancer (PrCa)-susceptibility loci}, journal = {Nature genetics}, doi = {10.1038/s41588-018-0142-8}, volume = {50}, number = {7}, issn = {1061-4036}, title = {Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci}, keyword = {prostate cancer (PrCa)-susceptibility loci} }
@article{article, author = {Schumacher, Fredrick R. and Al Olama, Ali Amin and Berndt, Sonja I. and Benlloch, Sara and Ahmed, Mahbubl and Saunders, Edward J. and Dadaev, Tokhir and Leongamornlert, Daniel and Anokian, Ezequiel and Cieza-Borrella, Clara and Goh, Chee and Brook, Mark N. and Sheng, Xin and Fachal, Laura and Dennis, Joe and Tyrer, Jonathan and Muir, Kenneth and Lophatananon, Artitaya and Stevens, Victoria L. and Gapstur, Susan M. and Carter, Brian D. and Tangen, Catherine M. and Goodman, Phyllis J. and Thompson, Ian M. and Batra, Jyotsna and Chambers, Suzanne and Moya, Leire and Clements, Judith and Horvath, Lisa and Tilley, Wayne and Risbridger, Gail P. and Gronberg, Henrik and Aly, Markus and Nordstr\"{o}m, Tobias and Pharoah, Paul and Pashayan, Nora and Schleutker, Johanna and Tammela, Teuvo L. J. and Sipeky, Csilla and Auvinen, Anssi and Albanes, Demetrius and Weinstein, Stephanie and Wolk, Alicja and H\aakansson, Niclas and West, Catharine M. L. and Dunning, Alison M. and Burnet, Neil and Mucci, Lorelei A. and Giovannucci, Edward and Andriole, Gerald L. and Cussenot, Olivier and Cancel- Tassin, G\'{e}raldine and Koutros, Stella and Beane Freeman, Laura E. and Sorensen, Karina Dalsgaard and Orntoft, Torben Falck and Borre, Michael and Maehle, Lovise and Grindedal, Eli Marie and Neal, David E. and Donovan, Jenny L. and Hamdy, Freddie C. and Martin, Richard M. and Travis, Ruth C. and Key, Tim J. and Hamilton, Robert J. and Fleshner, Neil E. and Finelli, Antonio and Ingles, Sue Ann and Stern, Mariana C. and Rosenstein, Barry S. and Kerns, Sarah L. and Ostrer, Harry and Lu, Yong-Jie and Zhang, Hong-Wei and Feng, Ninghan and Mao, Xueying and Guo, Xin and Wang, Guomin and Sun, Zan and Giles, Graham G. and Southey, Melissa C. and MacInnis, Robert J. and FitzGerald, Liesel M. and Kibel, Adam S. and Drake, Bettina F. and Vega, Ana and G\'{o}mez-Caama\~{n}o, Antonio and Szulkin, Robert and Eklund, Martin and Kogevinas, Manolis and Llorca, Javier and Casta\~{n}o-Vinyals, Gemma and Penney, Kathryn L. and Stampfer, Meir and Park, Jong Y. and Sellers, Thomas A. and Lin, Hui-Yi and Stanford, Janet L. and Cybulski, Cezary and Wokolorczyk, Dominika and Lubinski, Jan and Ostrander, Elaine A. and Geybels, Milan S. and Nordestgaard, B\orge G. and Nielsen, Sune F. and Weischer, Maren and Bisbjerg, Rasmus and R\oder, Martin Andreas and Iversen, Peter and Brenner, Hermann and Cuk, Katarina and Holleczek, Bernd and Maier, Christiane and Luedeke, Manuel and Schnoeller, Thomas and Kim, Jeri and Logothetis, Christopher J. and John, Esther M. and Teixeira, Manuel R. and Paulo, Paula and Cardoso, Marta and Neuhausen, Susan L. and Steele, Linda and Ding, Yuan Chun and De Ruyck, Kim and De Meerleer, Gert and Ost, Piet and Razack, Azad and Lim, Jasmine and Teo, Soo-Hwang and Lin, Daniel W. and Newcomb, Lisa F. and Lessel, Davor and Gamulin, Marija and Kuli\v{s}, Tomislav and Kaneva, Radka and Usmani, Nawaid and Singhal, Sandeep and Slavov, Chavdar and Mitev, Vanio and Parliament, Matthew and Claessens, Frank and Joniau, Steven and Van den Broeck, Thomas and Larkin, Samantha and Townsend, Paul A. and Aukim-Hastie, Claire and Gago-Dominguez, Manuela and Castelao, Jose Esteban and Martinez, Maria Elena and Roobol, Monique J. and Jenster, Guido and van Schaik, Ron H. N. and Menegaux, Florence and Truong, Th\'{e}r\`{e}se and Koudou, Yves Akoli and Xu, Jianfeng and Khaw, Kay-Tee and Cannon-Albright, Lisa and Pandha, Hardev and Michael, Agnieszka and Thibodeau, Stephen N. and McDonnell, Shannon K. and Schaid, Daniel J. and Lindstrom, Sara and Turman, Constance and Ma, Jing and Hunter, David J. and Riboli, Elio and Siddiq, Afshan and Canzian, Federico and Kolonel, Laurence N. and Le Marchand, Loic and Hoover, Robert N. and Machiela, Mitchell J. and Cui, Zuxi and Kraft, Peter and Amos, Christopher I. and Conti, David V. and Easton, Douglas F. and Wiklund, Fredrik and Chanock, Stephen J. and Henderson, Brian E. and Kote-Jarai, Zsofia and Haiman, Christopher A. and Eeles, Rosalind A.}, year = {2018}, pages = {928-936}, DOI = {10.1038/s41588-018-0142-8}, keywords = {prostate cancer (PrCa)-susceptibility loci}, journal = {Nature genetics}, doi = {10.1038/s41588-018-0142-8}, volume = {50}, number = {7}, issn = {1061-4036}, title = {Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci}, keyword = {prostate cancer (PrCa)-susceptibility loci} }

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