Naslov
Lymphoproliferative Lesions in Salivary Glands

Autori
Milković Periša, Marija ; Korać, Petra ; Šitić, Sanda ; Borovečki, Ana

Izvornik
Acta clinica Croatica (0353-9466) 43 (2004), 2; 232-232

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, stručni

Ključne riječi
Lymphoproliferative Lesions ; Salivary Glands

Sažetak
The etiopathogenesis of extranodal lymphomas is sup-posed to be associated with longlasting pre- existing inflam-matory or autoimmune lesion, which can stimulate prolif-eration and transformation of lymphatic tissue. The mostcommon primary salivary gland lymphoma is MALT typelymphoma. It differs from gastric MALT lymphoma in bcl-10 expression. During the 1992-2004 period, salivary glandsin 151 patients were morphologically analyzed, 111 of themparotid and 40 submandibular glands. The analysis yield-ed the following results: 89 patients had benign and ma-lignant epithelial changes, 35 showed lymphatic tissueproliferation, 12 had chronic inflammatory changes, 12were free from any morphological changes, and 3 hadmetastatic tumors, whereas inadequate material for anal-ysis was obtained in one patient. The aim of the study wasto define the type of lymphocytic expression and presence/absence of bcl-10 in 35 patients with lymphocytic prolif-eration and transformation. The slides were routinely pro- cessed (H&E, Giemsa). The phenotype was defined byCD20, CD3, CD79a, IgM, CD21, CD5 and CD10 mono- clonal antibodies. Clonality was determined by PCR meth-od and immunohistochemistry was used to detect expres-sion and localization of bcl-10 oncogen positivity (MoAbZymed Laboratories Corp.).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA