Naslov
Durable HIV-1 viral-load suppression in patients in Croatia in the period 2005 to 2015

Autori
Begovac, Josip ; Zekan, Šime ; Lukas, Davorka ; Božičević, Ivana ; Židovec Lepej, Snježana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
27th ECCMID 2017

Mjesto i datum
Beč, Austrija, 22.04.2017. - 25.04.2017

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HIV-1 ; viral load ; Croatia

Sažetak
Background: Croatia has a centralized system of HIV-care and all patients are treated at one centre. The HIV cascade of care uses a single viral load (VL) test per patient to estimate the prevalence of viral suppression. We compared this cross-sectional approach with a longitudinal approach by examining viral suppression in 3 consecutive calendar years in a 11-year period. The evolution of durable viral suppression over time was also examined. Material/methods: We included persons ≥18 years old, receiving HIV care in the period 2005 to 2015, who resided in Croatia and had at least one VL test in each of 3 consecutive years starting with 2003. Durable viral suppression was defined as all VL values < 400 copies/mL in 3 consecutive calendar years with at least a 2 year-period of being undetectable. Durability of VL suppression in a particular calendar year was determined by the value of VL tests in that year and the previous two years. The cross-sectional data analysed VL tests closest to the end of a calendar year for the same cohort. Results of VL suppression are reported in percentages. Results: Of 794 persons included in the study, 670 (84.4%) had at least one 3-year period with durable VL suppression and 755 (95.1%) were on antiretroviral therapy (ART) (Table). The crosssectional data showed substantially higher rates of viral suppression compared to longitudinal data. However, the difference was less marked in 2015 (11%) compared to 2005 (26%). Conclusions: Analysing only one VL test overestimated the percent of HIV patients with durable suppressed viral load. The increasing trend in durable viral load suppression is encouraging and indicates usage of potent and better tolerable antiretroviral medications.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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