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Pregled bibliografske jedinice broj: 1259629

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

(Nagahama Study Group) Miyake, Masahiro; ...; Polašek, Ozren; ...; Yoshimura, Nagahisa; Nagahama Study Group
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia // Nature Communications, 6 (2015), 1; 6689, 9 doi:10.1038/ncomms7689 (međunarodna recenzija, članak, znanstveni)

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Naslov
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Autori
Miyake, Masahiro ; ... ; Polašek, Ozren ; ... ; Yoshimura, Nagahisa ; Nagahama Study Group

Kolaboracija
Nagahama Study Group

Izvornik
Nature Communications (2041-1723) 6 (2015), 1; 6689, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adolescent ; Adult ; Animals ; Asian Continental Ancestry Group ; Cohort Studies ; Cornea ; Disease Models, Animal ; European Continental Ancestry Group ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Immunohistochemistry ; Male ; Mice ; Middle Aged ; Myopia ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins ; Retina ; RNA, Messenger ; Severity of Illness Index ; Wnt Proteins ; Young Adult

Sažetak
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9, 804 Japanese individuals, which was extended with trans-ethnic replication in 2, 674 Chinese and 2, 690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta =3.9 × 10-13) and corneal curvature (Pmeta =2.9 × 10-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1, 478 Asian patients and 4, 689 controls (odds ratio (OR)meta =1.13, Pmeta =0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

(Nagahama Study Group) Miyake, Masahiro; ...; Polašek, Ozren; ...; Yoshimura, Nagahisa; Nagahama Study Group
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia // Nature Communications, 6 (2015), 1; 6689, 9 doi:10.1038/ncomms7689 (međunarodna recenzija, članak, znanstveni)
(Nagahama Study Group) (Nagahama Study Group) Miyake, M., ..., Polašek, O., ..., Yoshimura, N. & Nagahama Study Group (2015) Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia. Nature Communications, 6 (1), 6689, 9 doi:10.1038/ncomms7689.
@article{article, author = {Miyake, Masahiro and Pola\v{s}ek, Ozren and Yoshimura, Nagahisa}, year = {2015}, pages = {9}, DOI = {10.1038/ncomms7689}, chapter = {6689}, keywords = {Adolescent, Adult, Animals, Asian Continental Ancestry Group, Cohort Studies, Cornea, Disease Models, Animal, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Humans, Immunohistochemistry, Male, Mice, Middle Aged, Myopia, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins, Retina, RNA, Messenger, Severity of Illness Index, Wnt Proteins, Young Adult}, journal = {Nature Communications}, doi = {10.1038/ncomms7689}, volume = {6}, number = {1}, issn = {2041-1723}, title = {Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia}, keyword = {Adolescent, Adult, Animals, Asian Continental Ancestry Group, Cohort Studies, Cornea, Disease Models, Animal, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Humans, Immunohistochemistry, Male, Mice, Middle Aged, Myopia, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins, Retina, RNA, Messenger, Severity of Illness Index, Wnt Proteins, Young Adult}, chapternumber = {6689} }
@article{article, author = {Miyake, Masahiro and Pola\v{s}ek, Ozren and Yoshimura, Nagahisa}, year = {2015}, pages = {9}, DOI = {10.1038/ncomms7689}, chapter = {6689}, keywords = {Adolescent, Adult, Animals, Asian Continental Ancestry Group, Cohort Studies, Cornea, Disease Models, Animal, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Humans, Immunohistochemistry, Male, Mice, Middle Aged, Myopia, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins, Retina, RNA, Messenger, Severity of Illness Index, Wnt Proteins, Young Adult}, journal = {Nature Communications}, doi = {10.1038/ncomms7689}, volume = {6}, number = {1}, issn = {2041-1723}, title = {Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia}, keyword = {Adolescent, Adult, Animals, Asian Continental Ancestry Group, Cohort Studies, Cornea, Disease Models, Animal, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Humans, Immunohistochemistry, Male, Mice, Middle Aged, Myopia, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins, Retina, RNA, Messenger, Severity of Illness Index, Wnt Proteins, Young Adult}, chapternumber = {6689} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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