Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1259586

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

(Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)) Lagou, Vasiliki; ...; Polašek, Ozren; ...; Prokopenko, Inga; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability // Nature Communications, 12 (2021), 1; 24, 18 doi:10.1038/s41467-020-19366-9 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1259586 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Autori
Lagou, Vasiliki ; ... ; Polašek, Ozren ; ... ; Prokopenko, Inga ; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)

Kolaboracija
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)

Izvornik
Nature Communications (2041-1723) 12 (2021), 1; 24, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adult ; Anorexia Nervosa ; Blood Glucose ; European Continental Ancestry Group ; Fasting ; Female ; Gene Expression ; Genetic Loci ; Genome-Wide Association Study ; Glucose Intolerance ; Humans ; Insulin ; Insulin Receptor Substrate Proteins ; Insulin Resistance ; Kruppel-Like Transcription Factors ; Male ; Middle Aged ; Phenotype ; Sex Characteristics ; Sex Factors ; Waist-Hip Ratio

Sažetak
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73, 089/50, 404 women and 67, 506/47, 806 men) and sex-combined (151, 188/105, 056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

(Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)) Lagou, Vasiliki; ...; Polašek, Ozren; ...; Prokopenko, Inga; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability // Nature Communications, 12 (2021), 1; 24, 18 doi:10.1038/s41467-020-19366-9 (međunarodna recenzija, članak, znanstveni)
(Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)) (Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)) Lagou, V., ..., Polašek, O., ..., Prokopenko, I. & Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) (2021) Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications, 12 (1), 24, 18 doi:10.1038/s41467-020-19366-9.
@article{article, author = {Lagou, Vasiliki and Pola\v{s}ek, Ozren and Prokopenko, Inga}, year = {2021}, pages = {18}, DOI = {10.1038/s41467-020-19366-9}, chapter = {24}, keywords = {Adult, Anorexia Nervosa, Blood Glucose, European Continental Ancestry Group, Fasting, Female, Gene Expression, Genetic Loci, Genome-Wide Association Study, Glucose Intolerance, Humans, Insulin, Insulin Receptor Substrate Proteins, Insulin Resistance, Kruppel-Like Transcription Factors, Male, Middle Aged, Phenotype, Sex Characteristics, Sex Factors, Waist-Hip Ratio}, journal = {Nature Communications}, doi = {10.1038/s41467-020-19366-9}, volume = {12}, number = {1}, issn = {2041-1723}, title = {Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability}, keyword = {Adult, Anorexia Nervosa, Blood Glucose, European Continental Ancestry Group, Fasting, Female, Gene Expression, Genetic Loci, Genome-Wide Association Study, Glucose Intolerance, Humans, Insulin, Insulin Receptor Substrate Proteins, Insulin Resistance, Kruppel-Like Transcription Factors, Male, Middle Aged, Phenotype, Sex Characteristics, Sex Factors, Waist-Hip Ratio}, chapternumber = {24} }
@article{article, author = {Lagou, Vasiliki and Pola\v{s}ek, Ozren and Prokopenko, Inga}, year = {2021}, pages = {18}, DOI = {10.1038/s41467-020-19366-9}, chapter = {24}, keywords = {Adult, Anorexia Nervosa, Blood Glucose, European Continental Ancestry Group, Fasting, Female, Gene Expression, Genetic Loci, Genome-Wide Association Study, Glucose Intolerance, Humans, Insulin, Insulin Receptor Substrate Proteins, Insulin Resistance, Kruppel-Like Transcription Factors, Male, Middle Aged, Phenotype, Sex Characteristics, Sex Factors, Waist-Hip Ratio}, journal = {Nature Communications}, doi = {10.1038/s41467-020-19366-9}, volume = {12}, number = {1}, issn = {2041-1723}, title = {Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability}, keyword = {Adult, Anorexia Nervosa, Blood Glucose, European Continental Ancestry Group, Fasting, Female, Gene Expression, Genetic Loci, Genome-Wide Association Study, Glucose Intolerance, Humans, Insulin, Insulin Receptor Substrate Proteins, Insulin Resistance, Kruppel-Like Transcription Factors, Male, Middle Aged, Phenotype, Sex Characteristics, Sex Factors, Waist-Hip Ratio}, chapternumber = {24} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.