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Pregled bibliografske jedinice broj: 1259150

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelou, Evangelos; ...; Polašek, Ozren; ...; Elliott, Paul
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders // Nature Human Behaviour, 3 (2019), 9; 950-961 doi:10.1038/s41562-019-0653-z (međunarodna recenzija, članak, znanstveni)

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Naslov
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Autori
Evangelou, Evangelos ; ... ; Polašek, Ozren ; ... ; Elliott, Paul

Izvornik
Nature Human Behaviour (2397-3374) 3 (2019), 9; 950-961

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adult ; Aged ; Alcohol Drinking ; Alcoholism ; Brain ; European Continental Ancestry Group ; Female ; Genes ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Magnetic Resonance Imaging ; Male ; Mental Disorders ; Middle Aged ; Neuroimaging ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Schizophrenia

Sažetak
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480, 842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Ozren Polašek (autor)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov www.nature.com

Citiraj ovu publikaciju:

Evangelou, Evangelos; ...; Polašek, Ozren; ...; Elliott, Paul
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders // Nature Human Behaviour, 3 (2019), 9; 950-961 doi:10.1038/s41562-019-0653-z (međunarodna recenzija, članak, znanstveni)
Evangelou, E., ..., Polašek, O., ... & Elliott, P. (2019) New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature Human Behaviour, 3 (9), 950-961 doi:10.1038/s41562-019-0653-z.
@article{article, author = {Evangelou, Evangelos and Pola\v{s}ek, Ozren and Elliott, Paul}, year = {2019}, pages = {950-961}, DOI = {10.1038/s41562-019-0653-z}, keywords = {Adult, Aged, Alcohol Drinking, Alcoholism, Brain, European Continental Ancestry Group, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Schizophrenia}, journal = {Nature Human Behaviour}, doi = {10.1038/s41562-019-0653-z}, volume = {3}, number = {9}, issn = {2397-3374}, title = {New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders}, keyword = {Adult, Aged, Alcohol Drinking, Alcoholism, Brain, European Continental Ancestry Group, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Schizophrenia} }
@article{article, author = {Evangelou, Evangelos and Pola\v{s}ek, Ozren and Elliott, Paul}, year = {2019}, pages = {950-961}, DOI = {10.1038/s41562-019-0653-z}, keywords = {Adult, Aged, Alcohol Drinking, Alcoholism, Brain, European Continental Ancestry Group, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Schizophrenia}, journal = {Nature Human Behaviour}, doi = {10.1038/s41562-019-0653-z}, volume = {3}, number = {9}, issn = {2397-3374}, title = {New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders}, keyword = {Adult, Aged, Alcohol Drinking, Alcoholism, Brain, European Continental Ancestry Group, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Schizophrenia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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