Naslov
Regional differences between the frontal, occipital, and cingulate cortex of the human fetal brain during the subplate formation period

Autori
Junaković, Alisa ; Kopić, Janja ; Kostović, Ivica ; Krsnik, Željka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FENS Regional Abstract Book / - , 2023, 1-1

Skup
FENS Regional Meeting 2023

Mjesto i datum
Algarve, Portugal, 03.05.2023. - 05.05.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
subplate ; regional cortical differences ; occipital cortex ; frontal cortex

Sažetak
The human prenatal cortical development is characterized by transient fetal lamination. Subplate (SP) zone, one of the key components of early prenatal neuronal circuitry, is the most prominent fetal cortical compartment and a major site of synaptogenesis and neuronal differentiation. SP is formed between 13 and 15 postconceptional weeks (PCW) from the deep portion of the cortical plate (CP). SP compartment is not uniform across the brain hemisphere and some regional differences, especially between the parietal somatosensory and occipital visual cortex are already known. SP is thicker and more developed in associative brain areas containing more cortico-cortical connections, and it is thinner in the medial and ventral cortical portions. Using immunohistochemistry on formalin- fixed paraffin-embedded (FFPE) postmortem prenatal human brain tissue, we showed expression patterns of diverse cellular and molecular markers in different brain areas. We analyzed all transient compartments of the fetal cerebral wall (“compartmental approach”). Our results showed regional differences in the subplate volume, extracellular matrix (ECM) content, and axonal content. In the orbitofrontal cortex, the “double” cortical plate containing projection neurons was observed. The occipital cortex was characterized by a thinner SP and a sharper border between the SP and the IZ (external capsule), while the interhemispheric cingulate cortex shows differences in the CP delamination and SP formation. In conclusion, regional differences between the frontal, occipital, and cingulate cortex can be observed early during in utero development, even before 15 PCW, and before the Brodmann-type cortical arealization.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA