Naslov
Prenatal dorsoventral differentiation of the human cingulate cortex during the subplate formation period

Autori
Junaković, Alisa ; Kopić, Janja ; Duque, Alvaro ; Rakic, Pasko ; Krsnik, Željka ; Kostović, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EAN Abstract Book / - , 2023, 1-1

Skup
9th Congress of the European Academy of Neurology

Mjesto i datum
Budapest, Virtual, 01.07.2023. - 04.07.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
subplate ; cingulate cortex ; prenatal brain development

Sažetak
Introduction: The cingulate gyrus, a prominent part of the human limbic lobe located around the great commissure corpus callosum, integrates complex emotional, executive, motivational, and cognitive functions. The cingulate cortex during in utero development is composed of the dorsal isocortical and ventral mesocortical/allocortical parts. The objective of our study was to reveal the laminar development of the various cingulate regions during the subplate (SP) formation period from 13 to 15 postconceptional weeks (PCW) before forming Brodmann-type arealization. Methods: The study was performed by analysis of deep projection neuron (DPN) markers laminar dynamics in all transient cortical compartments from the ventricles to the pia, emphasizing the SP zone formation from the deep cortical plate (CP). We utilized immunohistochemistry and immunofluorescence of diverse molecular markers on the paraffin-embedded human prenatal brain tissue. Results: Our results showed that the increased width of the marginal zone (MZ) towards the cortical limbus, parallel with the CP narrowing, and the subventricular zone (SVZ) diminishment were reliable landmarks of early allocortical/mesocortical differentiation. In addition, the SP formation pattern was shown to be one of the crucial hallmarks for the dorsoventral differentiation of the cingulate gyrus and the early distinction of the dorsal and ventral cingulate cortical parts. Conclusion: Laminar dynamics of DPN markers, the SP formation pattern, and the SVZ size indicate regional cingulate cortex differentiation early in development, even before the complete corpus callosum formation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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