Naslov
Withdrawal of antiepileptic drugs – pro

Autori
Šulentić, Vlatko ; Petelin Gadže, Željka ; Nanković, Sibila ; Bujan Kovač, Andreja ; Mrak, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neurologia Croatica. Supplement, 67 (2018), 1 / - , 2018, 41-41

Skup
6. hrvatski kongres "Dileme u neurologiji"

Mjesto i datum
Poreč, Hrvatska, 02.10.2018. - 06.10.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
withdrawal ; antiepileptic drugs

Sažetak
Withdrawing an antiepileptic drugs (AEDs) presents a challenge in everyday clinical practice. Despite all insights thus far, there is no uniform approach to the reduction or withdrawal of antiepileptic therapy. Also, considering different types of seizures, causes of epilepsy, disease durations and remissions, as well as other comorbidities, it is not possible to generally talk about withdrawal of AEDs. When talking about withdrawing AEDs, the main reasons could be found in side effects of therapy, stigma, quality of life, and cognitive side effects. Considering that, it should also be noted that there is a certain percentage of patients that are inaccurately diagnosed with epilepsy. Patients who have pharmacoresistant epilepsy and are treated with neurosurgical methods are a specific group of patients. If the semiology of seizures is in correlation with changes in brain magnetic resonance imaging (MRI), and if complete lesion resection is possible, it would be beneficial to try withdrawal of AEDs. In our group of 80 patients with mesial temporal sclerosis and 30 patients with focal cortical dysplasia that were treated with resective neurosurgery, in the postoperative period withdrawal of AEDs was individualized. We also took in consideration the postoperative Engel score and brain MRI, type of surgery, epilepsy duration, number of AEDs used before the surgery, and cognitive status. Postoperative outcomes were satisfactory, favoring the possibility of reasonable withdrawal of antiepileptic therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA