Naslov
Vagus nerve stimulation in the treatment of patients with pharmacoresistant epilepsy: our 17 years' experience

Autori
Nanković, Sibila ; Hajnšek, Sanja ; Petelin Gadže, Željka ; Gran, Mrak ; Poljaković, Zdravka ; Šulentić, Vlatko ; Kovačević, Ivana ; Bujan Kovač, Andreja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Epilepsy in Africa: Briding the gap / - , 2014, 37-38

Skup
2nd African Epilepsy Congress

Mjesto i datum
Cape Town, Južna Afrika, 22.05.2014. - 24.05.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vagus nerve stimulation, pharmacoresistant epilepsy, treatment
(vagus nerve stimulation, pharmacoresistant epilepsy, treatmen)

Sažetak
Purpose: We have studied the efficacy of vagus nerve stimulation (VNS) in patients with pharmacorestatant epilepsy hospitalized in the Neurology Department of the University Hospital Centre Zagreb. Method: From 1997 to 2001 we have implanted VNS in 11 patients with pharmacoresistant epilepsy who were magnetic resonance imaging (MRI) negative and from 2007 to 2013 in 35 patients, 30 of them were MRI positive, and were inoperable due to localisation of the pathomorphologic changes (ganglioglioma, hamartoma, various types of cortical dysplasia, porencephalic cysts, bilateral hippocampal sclerosis), 5 were MRI negative. In the group of MRI negative patients 1 patient had complex partial seizures (CPS). 5 patients had CPS with secondary generalisation, 4 patients had primary generalised epilepsy (PGE), 1 patient had elementary partial seizures (EPS), CPS and generalised tonic clonic seizures (GTCS) 4 patients had Lennox Gastaut syndrome (LGS) and 1 had Dravet syndrome. In the group of MRI positive patents: 5 patients had EPS and/or CPS without secondary generalisation, 2 had EPS with secondary generalisation. 15 patients had CPS with secondary generalisation, 4 patients had EPA and/or CPS with secondary generalisation as well as atonic seizures, 3 patients had PGE and one patient had Lafora body disease (LBD). Results: After implantation of VNS there was significant decrease in mean seizure frequency in the group of MRI positive patients for about 51.4% and in the group of MRI negative patients about 66.78%. Four patients with LGS were seizure free. The most frequent side effects were hoarseness. throat pain and cough, but they were mild and transitory. Conclusion: VNS was effective made of therapy in our group of patients with pharmacoresistant epilepsy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA