Naslov
Heparin-induced thrombocytopenia

Autori
Bandić Pavlović, Daniela ; Tonković, Dinko ; Korolija Marinić, Dragan ; Martinović, Željka ; Drvar, Željko ; Baronica, Robert

Izvornik
Neurologia Croatica (0353-8842) 61 (2012), 2; 47-52

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
HIT, HITT, thrombosis, HIT-IgG, heparin, low-molecular-weight heparin, direct thrombin inhibitors

Sažetak
Heparin-induced thrombocytopenia (HIT) is an immune mediated syndrome induced by unfractionated heparin (UFH) and low-molecular weight heparin (LMWH) that results in hypercoagulate state with high morbidity and mortality due to venous and arterial thrombosis. Thrombocytopenia is oft en observable in patients with HIT. Diff erential diagnosis has a wide spectrum, from non- immunological to immunological (induced by medications like heparin, quindine, cephalosporins or autoimmune disorders) causes and, in this context, HIT should be considered. In this article, the main characteristics of HIT are reviewed, including immune response and pretest probability to diagnosis and treatment.

Izvorni jezik
Engleski

POVEZANOST RADA