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Pregled bibliografske jedinice broj: 1257733

Diaminocyclopentane-derived <i>O</i>-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease

Weber, Patrick; Mészáros, Zuzana; Jagečić, Denis; Hribljan, Valentina; Mitrečić, Dinko; Bojarová, Pavla; Slámová, Kristýna; Vrba, Jiří; Kulik, Natalia; Křen, Vladimír; Stütz, Arnold E.
Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease // Chemical Communications, 58 (2022), 63; 8838-8841 doi:10.1039/d2cc02712g (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1257733 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Diaminocyclopentane-derived <i>O</i>-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease

Autori
Weber, Patrick ; Mészáros, Zuzana ; Jagečić, Denis ; Hribljan, Valentina ; Mitrečić, Dinko ; Bojarová, Pavla ; Slámová, Kristýna ; Vrba, Jiří ; Kulik, Natalia ; Křen, Vladimír ; Stütz, Arnold E.

Izvornik
Chemical Communications (1359-7345) 58 (2022), 63; 8838-8841

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer, tau, O-GlcNAcase inhibitors

Sažetak
We developed potent and selective aminocyclopentane- derived inhibitors of human O-N- acetyl-β-D- glucosaminidase (OGA) implicated in Alzheimer's disease. For example compound 13 was a nanomolar OGA inhibitor with 92 000-fold selectivity over human HexB. It was non-toxic and increased protein O- GlcNAcylation in the culture of murine neural cells, showing new alternatives in the treatment of tauopathies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Dinko Mitrečić (autor)

Poveznice na cjeloviti tekst rada:

doi pubs.rsc.org

Citiraj ovu publikaciju:

Weber, Patrick; Mészáros, Zuzana; Jagečić, Denis; Hribljan, Valentina; Mitrečić, Dinko; Bojarová, Pavla; Slámová, Kristýna; Vrba, Jiří; Kulik, Natalia; Křen, Vladimír; Stütz, Arnold E.
Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease // Chemical Communications, 58 (2022), 63; 8838-8841 doi:10.1039/d2cc02712g (međunarodna recenzija, članak, znanstveni)
Weber, P., Mészáros, Z., Jagečić, D., Hribljan, V., Mitrečić, D., Bojarová, P., Slámová, K., Vrba, J., Kulik, N., Křen, V. & Stütz, A. (2022) Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease. Chemical Communications, 58 (63), 8838-8841 doi:10.1039/d2cc02712g.
@article{article, author = {Weber, Patrick and M\'{e}sz\'{a}ros, Zuzana and Jage\v{c}i\'{c}, Denis and Hribljan, Valentina and Mitre\v{c}i\'{c}, Dinko and Bojarov\'{a}, Pavla and Sl\'{a}mov\'{a}, Krist\'{y}na and Vrba, Ji\v{r}\'{\i} and Kulik, Natalia and K\v{r}en, Vladim\'{\i}r and St\"{u}tz, Arnold E.}, year = {2022}, pages = {8838-8841}, DOI = {10.1039/d2cc02712g}, keywords = {Alzheimer, tau, O-GlcNAcase inhibitors}, journal = {Chemical Communications}, doi = {10.1039/d2cc02712g}, volume = {58}, number = {63}, issn = {1359-7345}, title = {Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease}, keyword = {Alzheimer, tau, O-GlcNAcase inhibitors} }
@article{article, author = {Weber, Patrick and M\'{e}sz\'{a}ros, Zuzana and Jage\v{c}i\'{c}, Denis and Hribljan, Valentina and Mitre\v{c}i\'{c}, Dinko and Bojarov\'{a}, Pavla and Sl\'{a}mov\'{a}, Krist\'{y}na and Vrba, Ji\v{r}\'{\i} and Kulik, Natalia and K\v{r}en, Vladim\'{\i}r and St\"{u}tz, Arnold E.}, year = {2022}, pages = {8838-8841}, DOI = {10.1039/d2cc02712g}, keywords = {Alzheimer, tau, O-GlcNAcase inhibitors}, journal = {Chemical Communications}, doi = {10.1039/d2cc02712g}, volume = {58}, number = {63}, issn = {1359-7345}, title = {Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease}, keyword = {Alzheimer, tau, O-GlcNAcase inhibitors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index

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