Naslov
Rapid Response to the Editor regarding the journal article “Acute LDL-C reduction post ACS: strike early and strike strong: from evidence to clinical practice. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Association of Preventive Cardiology (EAPC) and the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy”

Autori
Borovac, Josip Anđelo

Izvornik
European Heart Journal. Acute Cardiovascular Care (2048-8734) 12 (2023), 5; 338-339

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
acute coronary syndrome ; LDL reduction ; cholesterol ; early statin loading ; preloading ; percutaneous coronary intervention ; PCI

Sažetak
The mechanisms behind very early statin use in ACS and their translation to clinical benefit are not fully elucidated, however, such effects could be explained by the multifactorial impact of statin treatment on molecular and cellular events that are fundamental to the pathogenesis of ACS. Such mechanisms, independent of the central action on atherogenic lipoproteins, include reduction of inflammation, modulation of thrombogenesis and thrombolysis, improvement of endothelial dysfunction, and amelioration of ischemia/reperfusion injury. It has been previously shown in clinical studies that statin preloading before percutaneous coronary intervention (PCI) can limit periprocedural microcirculatory damage, and significantly reduce the "no-reflow" phenomenon. It can elicit significant endothelial protection in chronic and acute coronary syndrome populations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA