Naslov
Long-term refractory frontal lobe epilepsy caused by focal cortical dysplasia with succeful outcome of neurosurgical treatment – two case reports

Autori
Kovačević, Ivana ; Hajnšek, Sanja ; Nanković, Sibila ; Šulentić, Vlatko ; Bujan Kovač, Andreja ; Mrak, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neurologia Croatica / Lušić, Ivo ; Bilić, Ivica ; Džamonja, Gordan - Zagreb : Denona, 2013, 83-83

Skup
VI. hrvatski neurološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Split, Hrvatska, 06.11.2013. - 10.11.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
epilepsija frontalnog režnja, refraktorna epilepsija, neurokirurško liječenje
(frontal lobe epilepsy, refractory epilepsy, neurosurgical treatment)

Sažetak
We report two cases of frontal lobe epilepsy due to focal cortical dysplasia (FCD). The first patient, a 58-year-old man, had his first seizure at the age of 4. He had complex partial seizures (CPS) with motor arrest, pseudoabsence, verbal automatisms (cursing, loud humming) and ambulatory automatisms. The second patient, a 26-year-old woman, had her first seizure at the age of 5, absence seizures registered by a neuropediatrician, and hypermotor CPS appeared in puberty, with a frightened appearance and hyperventilation, bimanual and bipedal automatisms, pelvic movement and verbal automatisms. Later she was treated for anxiety depressive and conversion disorder, and pseudoseizures. Seizures of both patients were of short duration, without secondary generalisation and postictal confusion. There was nocturnal occurrence at the beginning, and later during the day too, which were medically intractable from adolescence, with up to 4 seizures per day. Video EEG monitoring of both patients showed several seizures of described semiology. The first patient had irritative focal changes in the left frontotemporal region and the second one had irritative focus in the right frontotemporal region. Both patients had normal brain MRI 1.5 Tesla, but only brain MRI 3 Tesla showed FCD of the orbitofrontal cortes, confirmed by postprocessing with MAP07 software. They were both operated in the University Hospital Centre in Zagreb, the Department of Neurosurgery, in July this year. Since then, they have been seizure free. Both of them had a histopathological diagnosis of FCD type IIB. FCD are distinct subgroup of malformations of the cortical development with a favorable outcome after the resection, even in very long lasting pharmacoresistant epilepsies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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