Naslov
Immunological hypothesis of atherosclerosis

Autori
Stipić Marković, Asja ; Pekić, Petar ; Stipić, JAgoda ;

Izvornik
Neurologia Croatica (0353-8842) 52 (2003); 171-177

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
immunologic inflammation, atherosclerosis, risk factors

Sažetak
During the past decade, several new risk factors for atherosclerosis, including inflammation and infections, have been reported.Recent data suggests that the initial stage of atherosclerosis are of immunological nature.There is evidence of an autoimmune activation of specific T-cells against heat-shock proteins expressed on the surface of endothelial cells which are exposed to haemodynamic stress.Humoral and cellular immune mechanisms can be determined in the early subclinical stages of the disease.This immune process can be found even in children and is reversible in the abscence of other risk factors.In the presence of hypertension, hypoercholesterolaemia and other risk factors it becomes ireversible and enables the formation of atherosclerotic deposits with all the pathophysiological and functional consequences.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA