Naslov
Comparison of C-reactive protein values on Dymind DF50 CRP and DxC 700 AU analysers

Autori
Njire Bratičević, Marina ; Stanić, Ana ; Čolan, Nikolina ; Perović, Antonija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Biochem Med. 2022 ; 32(Suppl 1):S1-S232. / - Zagreb, 2022, 152-153

Skup
10. kongres Hrvatskog društva za medicinsku biokemiju i laboratorijsku medicinu = 10th Congress of the Croatian Society of Medical Biochemistry and Laboratory Medicine

Mjesto i datum
Zagreb, Hrvatska, 28.09.2022. - 01.10.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
comparison ; POCT ; CRP

Sažetak
Introduction: C-reactive protein (CRP) is one of the most sensitive acute phase proteins and a key diagnostic test in emergency medicine, especially in paediatric clinics. The aim of this study was to compare CRP values measured in whole blood samples on analyser Dymind DF50 CRP, intended as a pointof- care analyser for the Paediatric Emergency Department with values in serum samples on biochemistry analyser DxC 700 AU, used in laboratory. Materials and methods: Routine patient’s samples (N = 30) used for comparison were K2EDTA whole blood and serum with CRP concentration range from 0.6 to 295.2 mg/L. In whole blood samples, CRP was measured by immunonephelometric method on Dymind DF50 CRP analyser (Dymind Biotechnology Co, Shenzhen, China). In serum samples, CRP was measured by immunoturbidimetric method on DxC 700 AU (Beckman Coulter, Brea, USA). The results were statistically analysed with MedCalc statistical software (10.0.2.0. version, Ostend, Belgium). Passing-Bablok regression for method comparison was used. The obtained differences were compared with external quality assessment criteria, CROQALM (22%). Results: Passing-Bablok regression analysis showed linear relation between the two methods with slight slope, i.e., proportional deviation. Intercept was 0.593 (95% CI - 0.013 to 1.084) and slope was 0.842 (95% CI 0.811 to 0.886). Results ranging from 2.7 to 138 mg/L met the comparison criteria of 22% as middle bias was - 9.50% and range was from - 19.23% to 19.74%. The results ranging from 166.8 to 295.2 mg/L did not meet the comparison criteria of 22% as middle bias was - 41.06% and range was from - 26.32% to - 57.94%. Conclusion: C-reactive protein values measured on Dymind DF50 CRP are comparable with values measured on DxC 700 AU in concentration range from 2.7 to 138 mg/L. Values higher than 150 mg/L are not comparable, therefore in those patients, CRP values should be measured and followed on biochemistry analyser DxC700AU in laboratory.

Izvorni jezik
Engleski

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