Naslov
Potentially inappropriate prescribing in older adults in central and Eastern Europe: systematic literature review

Autori
Brkic J. ; Okuyan B. ; Kummer I. ; Reissigova J. ; Sesto S. ; Capiau A. ; Ortner Hadziabdic M. ; Tadic I. ; Tachkov K., Bobrova V. ; Fialova D.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
International journal od clinical pharmacy / - , 2021, 806-806

Skup
European Society of Clinical Pharmacy International Workshop on Malabsorption and Malnutrition, A Challenge for Clinical Pharmacists

Mjesto i datum
Online, 26.04.2021. - 27.04.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PIP, eldery people, prevalence

Sažetak
Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic, 2 Clinical Pharmacy Department, Faculty of Pharmacy, Marmara University, Istanbul, Turkey, 3 Department of Statistical Modelling, Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic, 4 Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia, 5 Department of Pharmacy, Ghent University Hospital, 6 Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium, 7 Centre for Applied Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia, 8 Department of Social Pharmacy and Pharmacoeconomic, Medical University of Sofia, Sofia, Bulgaria, 9 Institute of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia, 10Department of Geriatrics and Gerontology, 1st Faculty of Medicine, Prague, Czech Republic Background and Objective: Potentially inappropriate prescribing (PIP) in older adults is a serious issue associated with adverse health outcomes. Our aim was to systematically review the literature on the prevalence of PIP in older adults in Central and Eastern Europe (CEE). Setting and Method: We searched two electronic databases MEDLINE and Embase in June 2019 and reference lists of included studies and relevant reviews. We included studies that assessed the prevalence of PIP in older adults (aged 60 years and older) in all settings of care using validated tools. At least two authors independently selected studies, extracted data, assessed risk of bias (using Joanna Briggs Institute’s critical appraisal checklist for studies reporting prevalence data), and assessed certainty of evidence (according to GRADE approach). Meta- analysis was not appropriate due to large variations in outcome measurement across studies. Thus, we synthesized data using descriptive statistics—median, range and interquartile range. Main outcome measures: Prevalence of PIP in older adults. Results: Our search yielded 1890 records, of which we included 27 studies (28 records). The design of all studies was cross-sectional, except for one study that was uncontrolled before- after. Most studies were conducted in high-income countries of European Union 11 (EU11). Only explicit tools were used to measure PIP prevalence. The prevalence of PIP was: median 34.6%, minimum 6.5%, maximum 95.8%, interquartile range 25.9–63.2% ; 26 studies, 1, 139, 693 participants ; very low certainty of evidence. The median PIP prevalence was higher in studies conducted in long-term and outpatient care than in studies conducted in acute and community care (71.1 and 53.8% vs 34.5 and 31.5%, respectively). Surprisingly, the prevalence of PIP was higher in studies conducted after 2010 than before 2010 (55.0 vs 25.7%). Conclusion: This review has shown that PIP in older adults is prevalent in CEE countries. Further well-designed and well-reported cross-national studies need to be carried out. Grant support of research group: European Union’s Horizon 2020 research and innovation progamme under the Marie SkłodowskaCurie grant agreement No 764632. PROGRESS Q42, Faculty of Pharmacy, Charles University (KSKF-2 Assoc. Prof. Fialova), SVV 260417 and INOMED project (CZ.02.1.01/0.0/0.0/18_069/0010046). Disclosure of Interest: None Declared.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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