Naslov
Analytical applications of glassy carbon modified electrode based on new copper(II) complex for cysteine analysis

Autori
Ivana Škugor Rončević, Nives Vladislavić, Boris-Marko Kukovec, Marijo Buzuk, Maša Buljac

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts - 8th Regional Symposium on Electrochemistry of South-East Europe and 9th Kurt Schwabe Symposium / - , 2022, 172-172

Skup
8th Regional Symposium on Electrochemistry of South-East Europe ; 9th Kurt Schwabe Symposium

Mjesto i datum
Graz, Austrija, 11.07.2022. - 15.07.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Copper complexes ; Nicotinic acid ; Cysteine analysis

Sažetak
Copper complexes play an important role in catalyzing enzymatic activity, and consequently, some copper(II) carboxylates are used as pharmaceuticals. Apart from the importance of copper as a metal center in many biochemical processes, pyridinecarboxylic acids and their derivatives also play important roles in the metabolism of all living cells. Insufficient nicotinic acid cause diseases like anemia, headache, tiredness, nausea and skin infection. Cu(II) complexes with nicotinic acid also showed antimicrobial activity against Bacillus subtilis and super oxidedismutase (SOD) mimetic activity. In order to further understand the coordination chemistry of rigid carboxylate with N-donor ligands, we synthesized, by layering and characterized the copper(II) coordination compound with 2-hydroxynicotinic acid (2-OHnic). The structure characterizations were based on elemental analysis, electrospray ionization mass spectrometry (ESI-MS), matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOFMS) and single crystal X-ray diffraction analyses (SCXRD). The electrochemical properties of the compound were carefully investigated by cyclic voltammetry and a prepared coordination compound has been used to obtain modified electrodes with potential applications in cysteine analysis. Based on cyclic voltammetry measurement, the mechanisms for the Cys-SH oxidation have been discussed. Square wave voltammetry obtained a linear response between 0.2 and 20 μM with an estimated detection limit of 0.09 μM.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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