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Pregled bibliografske jedinice broj: 1253854

Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease


Manon‐Jensen, T.; Sun, S.; Lindholm, M.; Domislović, V.; Giuffrida, P.; Brinar, M.; Mazza, G.; Pinzani, M.; Krznarić, Željko; Di Sabatino, A. et al.
Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease // United European Gastroenterology Journal, 9 (2021), 2; 268-278 doi:10.1177/2050640620977371 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1253854 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease

Autori
Manon‐Jensen, T. ; Sun, S. ; Lindholm, M. ; Domislović, V. ; Giuffrida, P. ; Brinar, M. ; Mazza, G. ; Pinzani, M. ; Krznarić, Željko ; Di Sabatino, A. ; Karsdal, M. A. ; Mortensen, J. H.

Izvornik
United European Gastroenterology Journal (2050-6406) 9 (2021), 2; 268-278

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
collagen ; epithelium ; inflammatory bowel disease ; serological biomarker

Sažetak
Background: Impaired intestinal epithelial barrier is highly affected in inflammatory bowel disease. Transmembrane collagens connecting the epithelial cells to the extracellular matrix have an important role in epithelial cell homeostasis. Thus, we sought to determine whether the transmembrane type 23 collagen could serve as a surrogate marker for disease activity in patients with Crohn's disease and ulcerative colitis. Methods: We developed an enzyme-linked immunosorbent assay to detect the ectodomain of type 23 collagen (PRO-C23) in serum, followed by evaluation of its levels in both acute and chronic dextran sulphate sodium colitis models in rats and human inflammatory bowel disease cohorts. Serum from 44 Crohn's disease and 29 ulcerative colitis patients with active and inactive disease was included. Results: In the acute and chronic dextran sulphate sodium-induced rat colitis model, the PRO-C23 serum levels were significantly increased after colitis and returned to normal levels after disease remission. Serum levels of PRO-C23 were elevated in Crohn's disease (p < 0.05) and ulcerative colitis (p < 0.001) patients with active disease compared to healthy donors. PRO-C23 differentiated healthy donors from ulcerative colitis (area under the curve [AUC]: 0.81, p = 0.0009) and Crohn's disease (AUC: 0.70, p = 0.0124). PRO-C23 differentiated ulcerative colitis patients with active disease from those in remission (AUC: 0.75, p = 0.0219) and Crohn's disease patients with active disease from those in remission (AUC: 0.68, p = 0.05). Conclusion: PRO- C23 was elevated in rats with active colitis, and inflammatory bowel disease patients with active disease. Therefore, PRO-C23 may be used as a surrogate marker for monitoring disease activity in ulcerative colitis and Crohn's disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Željko Krznarić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Manon‐Jensen, T.; Sun, S.; Lindholm, M.; Domislović, V.; Giuffrida, P.; Brinar, M.; Mazza, G.; Pinzani, M.; Krznarić, Željko; Di Sabatino, A. et al.
Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease // United European Gastroenterology Journal, 9 (2021), 2; 268-278 doi:10.1177/2050640620977371 (međunarodna recenzija, članak, znanstveni)
Manon‐Jensen, T., Sun, S., Lindholm, M., Domislović, V., Giuffrida, P., Brinar, M., Mazza, G., Pinzani, M., Krznarić, Ž. & Di Sabatino, A. (2021) Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease. United European Gastroenterology Journal, 9 (2), 268-278 doi:10.1177/2050640620977371.
@article{article, author = {Manon‐Jensen, T. and Sun, S. and Lindholm, M. and Domislovi\'{c}, V. and Giuffrida, P. and Brinar, M. and Mazza, G. and Pinzani, M. and Krznari\'{c}, \v{Z}eljko and Di Sabatino, A. and Karsdal, M. A. and Mortensen, J. H.}, year = {2021}, pages = {268-278}, DOI = {10.1177/2050640620977371}, keywords = {collagen, epithelium, inflammatory bowel disease, serological biomarker}, journal = {United European Gastroenterology Journal}, doi = {10.1177/2050640620977371}, volume = {9}, number = {2}, issn = {2050-6406}, title = {Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease}, keyword = {collagen, epithelium, inflammatory bowel disease, serological biomarker} }
@article{article, author = {Manon‐Jensen, T. and Sun, S. and Lindholm, M. and Domislovi\'{c}, V. and Giuffrida, P. and Brinar, M. and Mazza, G. and Pinzani, M. and Krznari\'{c}, \v{Z}eljko and Di Sabatino, A. and Karsdal, M. A. and Mortensen, J. H.}, year = {2021}, pages = {268-278}, DOI = {10.1177/2050640620977371}, keywords = {collagen, epithelium, inflammatory bowel disease, serological biomarker}, journal = {United European Gastroenterology Journal}, doi = {10.1177/2050640620977371}, volume = {9}, number = {2}, issn = {2050-6406}, title = {Elevated ectodomain of type 23 collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in ulcerative colitis and Crohn's disease}, keyword = {collagen, epithelium, inflammatory bowel disease, serological biomarker} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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