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Pregled bibliografske jedinice broj: 1253848

Effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study

Albshesh, Ahmad; Taylor, Joshua; Savarino, Edoardo V.; Truyens, Marie; Armuzzi, Alessandro; Ribaldone, Davide G.; Shitrit, Ariella Bar-Gil; Fibelman, Morine; Molander, Pauliina; Liefferinckx, Claire et al.
effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study // Journal of clinical medicine, 10 (2021), 13; 2914, 13 doi:10.3390/jcm10132914 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1253848 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study
(Effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study)

Autori
Albshesh, Ahmad ; Taylor, Joshua ; Savarino, Edoardo V. ; Truyens, Marie ; Armuzzi, Alessandro ; Ribaldone, Davide G. ; Shitrit, Ariella Bar-Gil ; Fibelman, Morine ; Molander, Pauliina ; Liefferinckx, Claire ; Nancey, Stephane ; Korani, Mohamed ; Rutka, Mariann ; Barreiro-de Acosta, Manuel ; Domislovic, Viktor ; Suris, Gerard ; Eriksson, Carl ; Alves, Catarina ; Mpitouli, Afroditi ; di Jiang, Caroline ; Tepeš, Katja ; Coletta, Marina ; Foteinogiannopoulou, Kalliopi ; Gisbert, Javier P. ; Amir-Barak, Hadar ; Attauabi, Mohamed ; Seidelin, Jakob ; Afif, Waqqas ; Marinelli, Carla ; Lobaton, Triana ; Pugliese, Daniela ; Maharshak, Nitsan ; Cremer, Anneline ; Limdi, Jimmy K. ; Molnár, Tamás ; Otero-Alvarin, Borja ; Krznaric, Zeljko ; Magro, Fernando ; Karmiris, Konstantinos ; Raine, Tim ; Drobne, David ; Koutroubakis, Ioannis ; Chaparro, Maria ; Yanai, Henit ; Burisch, Johan ; Kopylov, Uri

Izvornik
Journal of clinical medicine (2077-0383) 10 (2021), 13; 2914, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Crohn’s disease ; anti-TNF failure ; treatment response ; treatment failure ; ustekinumab ; vedolizumab

Sažetak
Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn’s disease (CD) failing anti- Tumor necrosis factors (TNFs) ; however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described. Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD. Results: Two-hundred and four patients were included ; 156/204 (76%) patients received VDZ as a second- and UST as a third-class therapy (group A) ; the remaining 48/204 (24%) patients received UST as a second- and VDZ as a third-class therapy (group B). At week 16–22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9) ; 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52 ; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9) ; 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5). Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Željko Krznarić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Albshesh, Ahmad; Taylor, Joshua; Savarino, Edoardo V.; Truyens, Marie; Armuzzi, Alessandro; Ribaldone, Davide G.; Shitrit, Ariella Bar-Gil; Fibelman, Morine; Molander, Pauliina; Liefferinckx, Claire et al.
effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study // Journal of clinical medicine, 10 (2021), 13; 2914, 13 doi:10.3390/jcm10132914 (međunarodna recenzija, članak, znanstveni)
Albshesh, A., Taylor, J., Savarino, E., Truyens, M., Armuzzi, A., Ribaldone, D., Shitrit, A., Fibelman, M., Molander, P. & Liefferinckx, C. (2021) effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study. Journal of clinical medicine, 10 (13), 2914, 13 doi:10.3390/jcm10132914.
@article{article, author = {Albshesh, Ahmad and Taylor, Joshua and Savarino, Edoardo V. and Truyens, Marie and Armuzzi, Alessandro and Ribaldone, Davide G. and Shitrit, Ariella Bar-Gil and Fibelman, Morine and Molander, Pauliina and Liefferinckx, Claire and Nancey, Stephane and Korani, Mohamed and Rutka, Mariann and Barreiro-de Acosta, Manuel and Domislovic, Viktor and Suris, Gerard and Eriksson, Carl and Alves, Catarina and Mpitouli, Afroditi and di Jiang, Caroline and Tepe\v{s}, Katja and Coletta, Marina and Foteinogiannopoulou, Kalliopi and Gisbert, Javier P. and Amir-Barak, Hadar and Attauabi, Mohamed and Seidelin, Jakob and Afif, Waqqas and Marinelli, Carla and Lobaton, Triana and Pugliese, Daniela and Maharshak, Nitsan and Cremer, Anneline and Limdi, Jimmy K. and Moln\'{a}r, Tam\'{a}s and Otero-Alvarin, Borja and Krznaric, Zeljko and Magro, Fernando and Karmiris, Konstantinos and Raine, Tim and Drobne, David and Koutroubakis, Ioannis and Chaparro, Maria and Yanai, Henit and Burisch, Johan and Kopylov, Uri}, year = {2021}, pages = {13}, DOI = {10.3390/jcm10132914}, chapter = {2914}, keywords = {Crohn’s disease, anti-TNF failure, treatment response, treatment failure, ustekinumab, vedolizumab}, journal = {Journal of clinical medicine}, doi = {10.3390/jcm10132914}, volume = {10}, number = {13}, issn = {2077-0383}, title = {effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study}, keyword = {Crohn’s disease, anti-TNF failure, treatment response, treatment failure, ustekinumab, vedolizumab}, chapternumber = {2914} }
@article{article, author = {Albshesh, Ahmad and Taylor, Joshua and Savarino, Edoardo V. and Truyens, Marie and Armuzzi, Alessandro and Ribaldone, Davide G. and Shitrit, Ariella Bar-Gil and Fibelman, Morine and Molander, Pauliina and Liefferinckx, Claire and Nancey, Stephane and Korani, Mohamed and Rutka, Mariann and Barreiro-de Acosta, Manuel and Domislovic, Viktor and Suris, Gerard and Eriksson, Carl and Alves, Catarina and Mpitouli, Afroditi and di Jiang, Caroline and Tepe\v{s}, Katja and Coletta, Marina and Foteinogiannopoulou, Kalliopi and Gisbert, Javier P. and Amir-Barak, Hadar and Attauabi, Mohamed and Seidelin, Jakob and Afif, Waqqas and Marinelli, Carla and Lobaton, Triana and Pugliese, Daniela and Maharshak, Nitsan and Cremer, Anneline and Limdi, Jimmy K. and Moln\'{a}r, Tam\'{a}s and Otero-Alvarin, Borja and Krznaric, Zeljko and Magro, Fernando and Karmiris, Konstantinos and Raine, Tim and Drobne, David and Koutroubakis, Ioannis and Chaparro, Maria and Yanai, Henit and Burisch, Johan and Kopylov, Uri}, year = {2021}, pages = {13}, DOI = {10.3390/jcm10132914}, chapter = {2914}, keywords = {Crohn’s disease, anti-TNF failure, treatment response, treatment failure, ustekinumab, vedolizumab}, journal = {Journal of clinical medicine}, doi = {10.3390/jcm10132914}, volume = {10}, number = {13}, issn = {2077-0383}, title = {effectiveness of third-class biologic treatment in crohn’s disease: a multi-center retrospective cohort study}, keyword = {Crohn’s disease, anti-TNF failure, treatment response, treatment failure, ustekinumab, vedolizumab}, chapternumber = {2914} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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