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Pregled bibliografske jedinice broj: 1253823

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Chatzikonstantinou, Thomas; Kapetanakis, Anargyros; Scarfò, Lydia; Karakatsoulis, Georgios; Allsup, David; Cabrero, Alejandro Alonso; Andres, Martin; Antic, Darko; Baile, Mónica; Baliakas, Panagiotis et al.
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study // Leukemia, 35 (2021), 12; 3444-3454 doi:10.1038/s41375-021-01450-8 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1253823 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Autori
Chatzikonstantinou, Thomas ; Kapetanakis, Anargyros ; Scarfò, Lydia ; Karakatsoulis, Georgios ; Allsup, David ; Cabrero, Alejandro Alonso ; Andres, Martin ; Antic, Darko ; Baile, Mónica ; Baliakas, Panagiotis ; Bron, Dominique ; Capasso, Antonella ; Chatzileontiadou, Sofia ; Cordoba, Raul ; Correa, Juan-Gonzalo ; Cuéllar- García, Carolina ; De Paoli, Lorenzo ; De Paolis, Maria Rosaria ; Del Poeta, Giovanni ; Demosthenous, Christos ; Dimou, Maria ; Donaldson, David ; Doubek, Michael ; Efstathopoulou, Maria ; Eichhorst, Barbara ; El-Ashwah, Shaimaa ; Enrico, Alicia ; Espinet, Blanca ; Farina, Lucia ; Ferrari, Angela ; Foglietta, Myriam ; Frederiksen, Henrik ; Fürstenau, Moritz ; García-Marco, José A. ; García-Serra, Rocío ; Gentile, Massimo ; Gimeno, Eva ; Glenthøj, Andreas ; Gomes da Silva, Maria ; Gutwein, Odit ; Hakobyan, Yervand K. ; Herishanu, Yair ; Hernández-Rivas, José Ángel ; Herold, Tobias ; Innocenti, Idanna ; Itchaki, Gilad ; Jaksic, Ozren ; Janssens, Ann ; Kalashnikova, Оlga B. ; Kalicińska, Elżbieta ; Karlsson, Linda Katharina ; Kater, Arnon P. ; Kersting, Sabina ; Labrador, Jorge ; Lad, Deepesh ; Laurenti, Luca ; Levin, Mark-David ; Lista, Enrico ; Lopez-Garcia, Alberto ; Malerba, Lara ; Marasca, Roberto ; Marchetti, Monia ; Marquet, Juan ; Mattsson, Mattias ; Mauro, Francesca R. ; Milosevic, Ivana ; Mirás, Fatima ; Morawska, Marta ; Motta, Marina ; Munir, Talha ; Murru, Roberta ; Niemann, Carsten U. ; Rodrigues, Raquel Nunes ; Olivieri, Jacopo ; Orsucci, Lorella ; Papaioannou, Maria ; Pavlovsky, Miguel Arturo ; Piskunova, Inga ; Popov, Viola Maria ; Quaglia, Francesca Maria ; Quaresmini, Giulia ; Qvist, Kristian ; Reda, Gianluigi ; Rigolin, Gian Matteo ; Ruchlemer, Rosa ; Saghumyan, Gevorg ; Shrestha, Amit ; Šimkovič, Martin ; Špaček, Martin ; Sportoletti, Paolo ; Stanca, Oana ; Stavroyianni, Niki ; Tadmor, Tamar ; Te Raa, Doreen ; Tonino, Sanne H. ; Trentin, Livio ; Van Der Spek, Ellen ; van Gelder, Michel ; van Kampen, Roel ; Varettoni, Marzia ; Visentin, Andrea ; Vitale, Candida ; Wasik-Szczepanek, Ewa ; Wróbel, Tomasz ; San Segundo, Lucrecia Yáñez ; Yassin, Mohamed ; Coscia, Marta ; Rambaldi, Alessandro ; Montserrat, Emili ; Foà, Robin ; Cuneo, Antonio ; Stamatopoulos, Kostas ; Ghia, Paolo

Izvornik
Leukemia (0887-6924) 35 (2021), 12; 3444-3454

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CLL, COVID-19

Sažetak
Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04 ; HR = 1.79, 95% CI:1.04- 3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.

Izvorni jezik
Engleski



POVEZANOST RADA

Projekti:
IP-2018-01-3453 - Ciljano liječenje, stanični mikrookoliš i tumorska distribucija u kroničnoj limfocitnoj leukemiji (B-KLL) (TTMTDCLL) (Jakšić, Ozren, HRZZ - 2018-01) ( CroRIS)

Profili:

Avatar Url Ozren Jakšić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Chatzikonstantinou, Thomas; Kapetanakis, Anargyros; Scarfò, Lydia; Karakatsoulis, Georgios; Allsup, David; Cabrero, Alejandro Alonso; Andres, Martin; Antic, Darko; Baile, Mónica; Baliakas, Panagiotis et al.
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study // Leukemia, 35 (2021), 12; 3444-3454 doi:10.1038/s41375-021-01450-8 (međunarodna recenzija, članak, znanstveni)
Chatzikonstantinou, T., Kapetanakis, A., Scarfò, L., Karakatsoulis, G., Allsup, D., Cabrero, A., Andres, M., Antic, D., Baile, M. & Baliakas, P. (2021) COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study. Leukemia, 35 (12), 3444-3454 doi:10.1038/s41375-021-01450-8.
@article{article, author = {Chatzikonstantinou, Thomas and Kapetanakis, Anargyros and Scarf\`{o}, Lydia and Karakatsoulis, Georgios and Allsup, David and Cabrero, Alejandro Alonso and Andres, Martin and Antic, Darko and Baile, M\'{o}nica and Baliakas, Panagiotis and Bron, Dominique and Capasso, Antonella and Chatzileontiadou, Sofia and Cordoba, Raul and Correa, Juan-Gonzalo and Cu\'{e}llar- Garc\'{\i}a, Carolina and De Paoli, Lorenzo and De Paolis, Maria Rosaria and Del Poeta, Giovanni and Demosthenous, Christos and Dimou, Maria and Donaldson, David and Doubek, Michael and Efstathopoulou, Maria and Eichhorst, Barbara and El-Ashwah, Shaimaa and Enrico, Alicia and Espinet, Blanca and Farina, Lucia and Ferrari, Angela and Foglietta, Myriam and Frederiksen, Henrik and F\"{u}rstenau, Moritz and Garc\'{\i}a-Marco, Jos\'{e} A. and Garc\'{\i}a-Serra, Roc\'{\i}o and Gentile, Massimo and Gimeno, Eva and Glenth\oj, Andreas and Gomes da Silva, Maria and Gutwein, Odit and Hakobyan, Yervand K. and Herishanu, Yair and Hern\'{a}ndez-Rivas, Jos\'{e} \'{A}ngel and Herold, Tobias and Innocenti, Idanna and Itchaki, Gilad and Jaksic, Ozren and Janssens, Ann and Kalashnikova, Оlga B. and Kalici\'{n}ska, El\.{z}bieta and Karlsson, Linda Katharina and Kater, Arnon P. and Kersting, Sabina and Labrador, Jorge and Lad, Deepesh and Laurenti, Luca and Levin, Mark-David and Lista, Enrico and Lopez-Garcia, Alberto and Malerba, Lara and Marasca, Roberto and Marchetti, Monia and Marquet, Juan and Mattsson, Mattias and Mauro, Francesca R. and Milosevic, Ivana and Mir\'{a}s, Fatima and Morawska, Marta and Motta, Marina and Munir, Talha and Murru, Roberta and Niemann, Carsten U. and Rodrigues, Raquel Nunes and Olivieri, Jacopo and Orsucci, Lorella and Papaioannou, Maria and Pavlovsky, Miguel Arturo and Piskunova, Inga and Popov, Viola Maria and Quaglia, Francesca Maria and Quaresmini, Giulia and Qvist, Kristian and Reda, Gianluigi and Rigolin, Gian Matteo and Ruchlemer, Rosa and Saghumyan, Gevorg and Shrestha, Amit and \v{S}imkovi\v{c}, Martin and \v{S}pa\v{c}ek, Martin and Sportoletti, Paolo and Stanca, Oana and Stavroyianni, Niki and Tadmor, Tamar and Te Raa, Doreen and Tonino, Sanne H. and Trentin, Livio and Van Der Spek, Ellen and van Gelder, Michel and van Kampen, Roel and Varettoni, Marzia and Visentin, Andrea and Vitale, Candida and Wasik-Szczepanek, Ewa and Wr\'{o}bel, Tomasz and San Segundo, Lucrecia Y\'{a}\~{n}ez and Yassin, Mohamed and Coscia, Marta and Rambaldi, Alessandro and Montserrat, Emili and Fo\`{a}, Robin and Cuneo, Antonio and Stamatopoulos, Kostas and Ghia, Paolo}, year = {2021}, pages = {3444-3454}, DOI = {10.1038/s41375-021-01450-8}, keywords = {CLL, COVID-19}, journal = {Leukemia}, doi = {10.1038/s41375-021-01450-8}, volume = {35}, number = {12}, issn = {0887-6924}, title = {COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study}, keyword = {CLL, COVID-19} }
@article{article, author = {Chatzikonstantinou, Thomas and Kapetanakis, Anargyros and Scarf\`{o}, Lydia and Karakatsoulis, Georgios and Allsup, David and Cabrero, Alejandro Alonso and Andres, Martin and Antic, Darko and Baile, M\'{o}nica and Baliakas, Panagiotis and Bron, Dominique and Capasso, Antonella and Chatzileontiadou, Sofia and Cordoba, Raul and Correa, Juan-Gonzalo and Cu\'{e}llar- Garc\'{\i}a, Carolina and De Paoli, Lorenzo and De Paolis, Maria Rosaria and Del Poeta, Giovanni and Demosthenous, Christos and Dimou, Maria and Donaldson, David and Doubek, Michael and Efstathopoulou, Maria and Eichhorst, Barbara and El-Ashwah, Shaimaa and Enrico, Alicia and Espinet, Blanca and Farina, Lucia and Ferrari, Angela and Foglietta, Myriam and Frederiksen, Henrik and F\"{u}rstenau, Moritz and Garc\'{\i}a-Marco, Jos\'{e} A. and Garc\'{\i}a-Serra, Roc\'{\i}o and Gentile, Massimo and Gimeno, Eva and Glenth\oj, Andreas and Gomes da Silva, Maria and Gutwein, Odit and Hakobyan, Yervand K. and Herishanu, Yair and Hern\'{a}ndez-Rivas, Jos\'{e} \'{A}ngel and Herold, Tobias and Innocenti, Idanna and Itchaki, Gilad and Jaksic, Ozren and Janssens, Ann and Kalashnikova, Оlga B. and Kalici\'{n}ska, El\.{z}bieta and Karlsson, Linda Katharina and Kater, Arnon P. and Kersting, Sabina and Labrador, Jorge and Lad, Deepesh and Laurenti, Luca and Levin, Mark-David and Lista, Enrico and Lopez-Garcia, Alberto and Malerba, Lara and Marasca, Roberto and Marchetti, Monia and Marquet, Juan and Mattsson, Mattias and Mauro, Francesca R. and Milosevic, Ivana and Mir\'{a}s, Fatima and Morawska, Marta and Motta, Marina and Munir, Talha and Murru, Roberta and Niemann, Carsten U. and Rodrigues, Raquel Nunes and Olivieri, Jacopo and Orsucci, Lorella and Papaioannou, Maria and Pavlovsky, Miguel Arturo and Piskunova, Inga and Popov, Viola Maria and Quaglia, Francesca Maria and Quaresmini, Giulia and Qvist, Kristian and Reda, Gianluigi and Rigolin, Gian Matteo and Ruchlemer, Rosa and Saghumyan, Gevorg and Shrestha, Amit and \v{S}imkovi\v{c}, Martin and \v{S}pa\v{c}ek, Martin and Sportoletti, Paolo and Stanca, Oana and Stavroyianni, Niki and Tadmor, Tamar and Te Raa, Doreen and Tonino, Sanne H. and Trentin, Livio and Van Der Spek, Ellen and van Gelder, Michel and van Kampen, Roel and Varettoni, Marzia and Visentin, Andrea and Vitale, Candida and Wasik-Szczepanek, Ewa and Wr\'{o}bel, Tomasz and San Segundo, Lucrecia Y\'{a}\~{n}ez and Yassin, Mohamed and Coscia, Marta and Rambaldi, Alessandro and Montserrat, Emili and Fo\`{a}, Robin and Cuneo, Antonio and Stamatopoulos, Kostas and Ghia, Paolo}, year = {2021}, pages = {3444-3454}, DOI = {10.1038/s41375-021-01450-8}, keywords = {CLL, COVID-19}, journal = {Leukemia}, doi = {10.1038/s41375-021-01450-8}, volume = {35}, number = {12}, issn = {0887-6924}, title = {COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study}, keyword = {CLL, COVID-19} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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