Naslov
An unusual case of acute myopericarditis after the first dose of capecitabine: Need for new cardioprotective strategies and risk stratification

Autori
Meter, Mijo ; Gavran, Ivana ; Bajo, Diana ; Duplančić, Darko

Izvornik
International journal of clinical pharmacology and therapeutics (0946-1965) 59 (2021), 12; 775-779

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
colorectal cancer ; chemotherapy ; capecitabine ; myopericarditis

Sažetak
Background: Fluoropyrimidines 5-fluorouracil (5- FU) and capecitabine are antimetabolite drugs used for the treatment of colorectal, breast, head, and neck malignancies. Different clinical manifestations of fluoropyrimidine-induced cardio- toxicity (FIC) have been reported in the literature. Case report: A 46-year-old female patient with a history of colorectal adenocarcinoma presented to the Emergency Department due to chest pain and mildly elevated cardiac serum troponin levels. Three days earlier, she had received a first adjuvant chemotherapy treatment with oral capecitabine. After the exclusion of obstructive coronary artery disease (CAD), acute myopericarditis was suspected. Conclusion: Capecitabine-induced myopericarditis is an extremely rare but important clinical condition to be recognized and treated promptly in order to prevent potentially lethal consequences of cardiac dysfunction.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA