Naslov
Impact of sleep apnea on the overall cardioembolic risk in patients with atrial fibrillation: a cross-sectional analysis of the ESADA cohort

Autori
Pengo, M. F. ; Faini, A. ; Grote, L. ; Ludka, O. ; Joppa, P. ; Pataka, A. ; Đogaš, Zoran ; Mihaicuta, S. ; Hein, H. ; Anttalainen, U. ; Ryan, S. ; Lombardi, C. ; Parati, G.

Kolaboracija
European Sleep Apnoea Database (ESADA)

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
JOURNAL OF SLEEP RESEARCH / - , 2020, 2-3

Skup
25th Congress of the European Sleep Research Society (ESRS)

Mjesto i datum
Online, 22.09.2020. - 24.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sleep apnea ; atrial fibrillation ; cardioembolic risk

Sažetak
Objectives/Introduction: Atrial fibrillation (AF) is the most common supra-ventricular arrhythmia worldwide and is one of the causes of ischemic stroke. Obstructive sleep apnea (OSA) and AF often coexist and share several predisposing factors. In patients with AF, assessment of thromboembolic risk, and subsequent use of appropriate therapy is crucial for stroke prevention. The aim of the present study is to understand if the presence of OSA carries a significant additional cardioembolic risk to patients with AF. Methods: The ESADA Study prospectively collects data from unselected adult patients aged 18–80 years with suspected OSA referred European sleep centres. In the present study, patients with OSA and AF were included and the CHA2DS2-VASc score was calculated according to current guidelines. Based on ESC guidelines on AF, patients were stratified into 3 risk categories: low, moderate and high risk of cardio-embolic events. Results: Cross-sectional data of 14646 patients were included in the analysis. From the total sample, a cohort of 363 patients with AF was analysed. The distribution of CHADVASC score is shown in figure 1. ODI, but not AHI, was significantly increased in category 1 and ≥2 when compared to low cardioembolic risk (Chi-squared p-value <0.01). Similarly, lowest SpO2 was significantly reduced with the increase of CHADVASC risk score categories. Conclusions: The analysis of the ESADA cohort confirms that OSA severity is associated with an increased cardioembolic risk in patients with atrial fibrillation. In particular, ODI but not AHI showed a significant association with CHADVASC score suggesting a potential role of intermittent hypoxia in the risk of developing cardio embolic complications such as stroke in patients with OSA and AF.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA